{"id":"W1999483871","doi":"10.1126/science.1245627","title":"Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer","year":2013,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":709,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Trimer; Chemistry; Antigenicity; Glycoprotein; Infectivity; Immunoglobulin Fab Fragments; Biophysics; Antibody; Virology; Crystallography; Virus; Peptide sequence; Biology; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603504,0.0004467289,0.0002309982,0.0002000428,0.0007520491,0.0004316188,0.0008321572,0.001165408,0.00450445],"category_scores_gemma":[0.0002408279,0.0003235679,0.0002912201,0.0002864717,0.0004672897,0.0006385444,0.0002953153,0.001489528,0.0007668936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008284596,"about_ca_system_score_gemma":0.0007113524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008957396,"about_ca_topic_score_gemma":0.008422263,"domain_scores_codex":[0.9999461,0.000005654721,0.000002396306,0.000009680496,0.00002132047,0.00001487748],"domain_scores_gemma":[0.9998909,0.00002942043,0.00001743808,0.000008450875,0.00002927682,0.0000245253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00437841,0.001305318,0.01858098,0.002155095,0.0006246606,0.01185516,0.001760127,0.1389471,0.7181752,0.01376456,0.05819914,0.03025417],"study_design_scores_gemma":[0.0006529395,0.001735026,0.1758218,0.0007115175,0.0004855016,0.007956032,0.002706733,0.5531344,0.1695055,0.008030646,0.07895914,0.0003007011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9459259,0.004092423,0.01455219,0.002894123,0.0002202689,0.0001039747,0.006794709,0.001004998,0.02441155],"genre_scores_gemma":[0.9570351,0.00401279,0.02069044,0.0006054228,0.00004821838,0.00008585861,0.01008301,0.0002229096,0.007216133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008957396,"threshold_uncertainty_score":0.01781052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085715458381893,"score_gpt":0.2485637774608344,"score_spread":0.2377066228770155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}