{"id":"W1999505686","doi":"10.1182/blood-2010-04-280149","title":"EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":297,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"PRC2; EZH2; Biology; Chromatin immunoprecipitation; Germinal center; Histone H3; Gene silencing; Cancer research; Epigenetics; H3K4me3; DNA methylation; Cell cycle; Chromatin; Molecular biology; Promoter; Cell biology; B cell; Cell; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887837,0.0001132214,0.0001085404,0.00007459109,0.00004623285,0.00003466169,0.00007087237,0.0001418754,0.000006830498],"category_scores_gemma":[0.0001205465,0.0001145342,0.00002481108,0.00009181224,0.00002646147,0.000002912044,0.00005633145,0.00005708676,0.000007864423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004894186,"about_ca_system_score_gemma":0.00004610571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002239713,"about_ca_topic_score_gemma":0.0002855788,"domain_scores_codex":[0.9992096,0.00003774614,0.0001953905,0.0002800655,0.00007521327,0.0002020125],"domain_scores_gemma":[0.999613,0.00001987944,0.00004201994,0.0001736383,0.00006424025,0.00008714574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001684427,0.00008193907,0.1211916,0.000008470064,0.000009606141,0.000002289263,0.00004273041,0.00001477915,0.8767584,0.000006223814,0.00000801637,0.001859103],"study_design_scores_gemma":[0.001038121,0.0000997921,0.1372572,0.000007440546,0.00001375453,0.00000247567,0.00001382712,0.0000648667,0.8601418,0.00003622469,0.001208668,0.0001158799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981856,0.0006481924,0.0005322344,0.00009441393,0.0001351638,0.0002545246,0.0000184525,0.000007036318,0.000124375],"genre_scores_gemma":[0.9983566,0.0001625713,0.001041826,0.0001087201,0.0001585645,0.00003435624,0.00006261667,0.00001521955,0.00005948474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01661662,"threshold_uncertainty_score":0.4670568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003955922946880838,"score_gpt":0.2182357438659096,"score_spread":0.2142798209190288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}