{"id":"W1999505686","doi":"10.1182/blood-2010-04-280149","title":"EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":297,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"PRC2; EZH2; Biology; Chromatin immunoprecipitation; Germinal center; Histone H3; Gene silencing; Cancer research; Epigenetics; H3K4me3; DNA methylation; Cell cycle; Chromatin; Molecular biology; Promoter; Cell biology; B cell; Cell; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009110397,0.0002778513,0.0001988751,0.0002367316,0.0001479875,0.0002768314,0.0001518091,0.0002073506,0.001076332],"category_scores_gemma":[0.00009161963,0.0001179356,0.0001129676,0.0001658691,0.0001999795,0.0001645858,0.0002878724,0.0003248107,0.0002997072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002857796,"about_ca_system_score_gemma":0.0001468314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000476833,"about_ca_topic_score_gemma":0.0006709577,"domain_scores_codex":[0.9999247,0.000009819742,0.000003983819,0.00002094229,0.00001999963,0.00002056543],"domain_scores_gemma":[0.9999508,0.000004391482,0.00001359399,0.000004332826,0.000005888558,0.00002105316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001796437,0.00001943813,0.002027929,0.00005535359,0.00000976503,0.0001907352,0.00002269251,0.00008642123,0.9922031,0.000316974,0.0001646274,0.004723232],"study_design_scores_gemma":[0.00009858153,0.0002952153,0.1568908,0.00001441524,0.00006393294,0.001726959,0.0001232498,0.002340394,0.8209475,0.0006204704,0.01686588,0.000012576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986814,0.007114437,0.002682983,0.0001865186,0.00002848666,0.00001699651,0.0002693461,0.0001420065,0.002745133],"genre_scores_gemma":[0.9952981,0.001509771,0.0004563371,0.00004775646,0.00001860895,0.00001267662,0.0002475042,0.000009123489,0.002400183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076332,"threshold_uncertainty_score":0.003600717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003955922946880838,"score_gpt":0.2182357438659096,"score_spread":0.2142798209190288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}