{"id":"W1999507887","doi":"10.1016/j.ejmech.2014.09.029","title":"Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Natural Science Foundation of China; St. Francis Xavier University","keywords":"Antimycobacterial; Klebsiella pneumoniae; Chemistry; Oxime; Moiety; Antibacterial activity; In vitro; In vivo; Escherichia coli; Antibacterial agent; Microbiology; Stereochemistry; Antibiotics; Bacteria; Mycobacterium tuberculosis; Medicinal chemistry; Biochemistry; Biology; Tuberculosis; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002347212,0.0001723993,0.0002832087,0.00003057617,0.0000625733,0.00002060733,0.000176281,0.00009061606,0.0001281813],"category_scores_gemma":[0.0003051588,0.0001520137,0.00008151593,0.0000396647,0.0001473128,0.00001566451,0.00006173715,0.0001889473,7.539937e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002043202,"about_ca_system_score_gemma":0.0001358791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001938089,"about_ca_topic_score_gemma":3.724862e-7,"domain_scores_codex":[0.9983318,0.0003553335,0.0004815776,0.0002226943,0.00044294,0.0001655824],"domain_scores_gemma":[0.998665,0.00002693592,0.0005328402,0.0001975576,0.0004316735,0.0001459824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001035661,0.00005775191,0.0002653972,0.00003932746,0.0001138055,0.000004358955,0.00008694862,0.00001451407,0.9677094,0.00001174108,0.00006428541,0.03059686],"study_design_scores_gemma":[0.0025261,0.001133539,0.008990726,0.000144561,0.0002138808,0.0002885149,0.000227679,0.0001210286,0.9822357,0.00004777587,0.003900146,0.0001703837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994839,0.00060292,0.003167455,0.00008505484,0.0003845722,0.00006132483,0.00001029943,0.000004279271,0.0008450598],"genre_scores_gemma":[0.9966537,0.0002371216,0.000741775,0.00007679904,0.002209925,0.000001376074,0.00003434697,0.00002739382,0.00001753601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03042648,"threshold_uncertainty_score":0.6198938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02441884328696406,"score_gpt":0.2570297688768378,"score_spread":0.2326109255898737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}