{"id":"W1999507887","doi":"10.1016/j.ejmech.2014.09.029","title":"Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety","year":2014,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Natural Science Foundation of China; St. Francis Xavier University","keywords":"Antimycobacterial; Klebsiella pneumoniae; Chemistry; Oxime; Moiety; Antibacterial activity; In vitro; In vivo; Escherichia coli; Antibacterial agent; Microbiology; Stereochemistry; Antibiotics; Bacteria; Mycobacterium tuberculosis; Medicinal chemistry; Biochemistry; Biology; Tuberculosis; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583195,0.0003147199,0.0002818792,0.0002026982,0.0001480319,0.0001068856,0.0003052616,0.0002883245,0.001363651],"category_scores_gemma":[0.0001478736,0.000107932,0.0001594176,0.0001668558,0.000132924,0.0001623991,0.0001201235,0.0001815008,0.0002937112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001856543,"about_ca_system_score_gemma":0.0002502578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007469167,"about_ca_topic_score_gemma":0.001322069,"domain_scores_codex":[0.9999226,0.0000148338,0.000009954082,0.00001194356,0.00001405343,0.00002654359],"domain_scores_gemma":[0.999936,0.000008012286,0.00001603228,0.000008081629,0.00001409793,0.00001783547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005488583,0.00009606648,0.0001669643,0.0001783239,0.000008531973,0.0002994071,0.00004833222,0.0005392587,0.9882113,0.0002812446,0.0002278944,0.009393791],"study_design_scores_gemma":[0.0001403895,0.003372501,0.002142232,0.00001936756,0.00003674209,0.000309255,0.00002125859,0.0008694489,0.9860321,0.00005030868,0.006989071,0.00001726161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861503,0.004416574,0.003832085,0.0001357795,0.00006743841,0.000143236,0.0008321682,0.0001095782,0.004312697],"genre_scores_gemma":[0.9929096,0.001560476,0.003035084,0.00005240269,0.00001712858,0.0000395488,0.0004447098,0.000007622632,0.001933356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001363651,"threshold_uncertainty_score":0.004561901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02441884328696406,"score_gpt":0.2570297688768378,"score_spread":0.2326109255898737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}