{"id":"W1999513735","doi":"10.1080/00498250110100711","title":"SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: In vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man","year":2002,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Pharmacokinetics; In vivo; Pharmacology; In vitro; Microsome; Metabolism; Kinase; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159383,0.000161106,0.000243937,0.0001366001,0.00004799117,0.000008107404,0.00005528277,0.0001060148,0.00001094927],"category_scores_gemma":[0.00009795199,0.0001534563,0.00002374973,0.0002016549,0.0000737354,0.000007139141,0.0001036615,0.0001045504,9.284926e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001514907,"about_ca_system_score_gemma":0.00001368424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002889068,"about_ca_topic_score_gemma":0.0000452911,"domain_scores_codex":[0.9990432,0.00009457565,0.0002305025,0.0003353404,0.00008106482,0.0002153213],"domain_scores_gemma":[0.9996741,0.0000153442,0.00005843926,0.0001225977,0.00005813872,0.00007139715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002573341,0.00009863324,0.0002702744,0.00006278152,0.00003698036,0.000004381143,0.0009061596,0.000003577169,0.9970819,0.00001538522,0.0001352068,0.001127374],"study_design_scores_gemma":[0.001100535,0.0002910511,0.003075597,0.00005008081,0.00001871284,0.000005789342,0.0001327961,0.00007029834,0.9931371,0.00003481039,0.001919194,0.0001640261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955263,0.003425361,0.00001222214,0.0001779388,0.00006257693,0.0005612329,0.00002238673,0.000006730387,0.0002052643],"genre_scores_gemma":[0.9988658,0.0001880621,0.0005377222,0.00006938871,0.00007333355,0.00003998123,0.000006160157,0.00001507936,0.0002044021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003944803,"threshold_uncertainty_score":0.6257766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661729218222359,"score_gpt":0.2516120641375673,"score_spread":0.2349947719553437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}