{"id":"W1999534828","doi":"10.1007/s10989-005-6791-3","title":"In Search of Selective Inhibitors of Cysteine Protease, Cathepsin K","year":2005,"lang":"en","type":"article","venue":"International Journal of Peptide Research and Therapeutics","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Institute for Nanotechnology","funders":"","keywords":"Cysteine protease; Peptidomimetic; Cysteine; Cathepsin; Chemistry; Protease; Enzyme; Dissociation constant; Cathepsin B; Cathepsin L; Stereochemistry; Biochemistry; Cysteine Proteinase Inhibitors; Deubiquitinating enzyme; Combinatorial chemistry; Peptide; Ubiquitin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001038015,0.00007046772,0.0001384324,0.0002846072,0.00001733746,0.00001155365,0.0002457549,0.00007618299,0.000009730146],"category_scores_gemma":[0.00007814925,0.00005938294,0.00006130107,0.0001223848,0.0001372958,0.0000184952,0.00009095493,0.000246628,8.86022e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003948329,"about_ca_system_score_gemma":0.0002345377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004674323,"about_ca_topic_score_gemma":0.00002653252,"domain_scores_codex":[0.9986539,0.0001291375,0.0003796454,0.0001028837,0.0005754496,0.0001589188],"domain_scores_gemma":[0.9984353,0.00003745758,0.000149112,0.00008892073,0.001228143,0.0000610817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006769109,0.0002757429,0.001650897,0.00001532256,0.0001380784,0.00001066797,0.0002402436,0.00003569928,0.9917719,0.0005465127,0.0001711672,0.004466907],"study_design_scores_gemma":[0.0008866168,0.001509736,0.0003204318,0.00009432478,0.000004056251,0.00005675758,0.0001622869,0.00006546955,0.9915289,0.001471159,0.00384942,0.00005087864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969284,0.001526264,0.0002139149,0.000715114,0.00006328411,0.0001452393,0.00001419141,6.421481e-7,0.0003929831],"genre_scores_gemma":[0.9976883,0.0008111573,0.0008188901,0.00004880069,0.0004353634,0.000003350538,0.000003260182,0.000009248667,0.0001816182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004416028,"threshold_uncertainty_score":0.2421566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03355635755546485,"score_gpt":0.358191633753478,"score_spread":0.3246352761980131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}