{"id":"W1999562007","doi":"10.1016/j.bmcl.2010.07.076","title":"The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Chemistry; Drug discovery; Phosphodiesterase; Chemical synthesis; Enzyme inhibitor; Structure–activity relationship; Pharmacology; Enzyme; Biochemistry; Stereochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002979056,0.0004980132,0.0004782934,0.0003122798,0.0001845006,0.0004149936,0.0004995127,0.0003055088,0.001718013],"category_scores_gemma":[0.0002051287,0.0002894822,0.0002875978,0.0002258595,0.0001810505,0.0002909143,0.0004336028,0.0007834376,0.0005906459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005137993,"about_ca_system_score_gemma":0.0003386663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006419788,"about_ca_topic_score_gemma":0.001917544,"domain_scores_codex":[0.9999237,0.00000886864,0.000006158562,0.00001330626,0.00001591355,0.00003189833],"domain_scores_gemma":[0.9999627,0.000005565546,0.000007757558,0.000004250564,0.000007218396,0.00001242151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008626977,0.0003611871,0.0006419403,0.0007463229,0.00013901,0.000791182,0.0001607042,0.005868731,0.7967842,0.009598456,0.006486467,0.1775591],"study_design_scores_gemma":[0.001243284,0.003366151,0.00245158,0.00011243,0.0002678092,0.001740658,0.00009044327,0.007391341,0.8374102,0.003000868,0.1428386,0.00008652175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.780032,0.08775366,0.08662565,0.002819347,0.001129772,0.0008764051,0.004217909,0.0009209662,0.03562425],"genre_scores_gemma":[0.9098122,0.04515282,0.02570024,0.001095293,0.00012812,0.0002720054,0.002678756,0.00006571742,0.01509473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718013,"threshold_uncertainty_score":0.005747318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00287464642112334,"score_gpt":0.1901444957200641,"score_spread":0.1872698492989408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}