{"id":"W1999564272","doi":"10.1097/cad.0b013e3283287c20","title":"Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777","year":2009,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Prodrug; Pharmacokinetics; Pharmacology; Nicotinamide; Bolus (digestion); Therapeutic index; Chemistry; Mechanism of action; Medicine; In vitro; Drug; Internal medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002466294,0.0001765839,0.0001944931,0.00001925697,0.0001048131,0.00001505351,0.0004245464,0.0001697672,0.00003097441],"category_scores_gemma":[0.0000549619,0.0001249524,0.0001839404,0.0001532372,0.0001500608,0.000003759465,0.0001228262,0.0002085086,0.000006712698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002041717,"about_ca_system_score_gemma":0.0003392555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001838175,"about_ca_topic_score_gemma":0.00001731226,"domain_scores_codex":[0.9985008,0.00005989398,0.0003663263,0.0004190867,0.0003166456,0.0003372687],"domain_scores_gemma":[0.9992705,0.000009324667,0.00007144794,0.0004250845,0.0001181001,0.000105534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001068477,0.000230242,0.001164204,0.00003149959,0.00004500541,5.295729e-7,0.0001411337,0.000003687048,0.9608031,0.00003967912,0.001730332,0.03570372],"study_design_scores_gemma":[0.0006086248,0.00009119721,0.005498431,0.00005315959,0.00001422361,0.000001336807,0.00002634975,0.000006779468,0.9554971,0.00002976457,0.03800263,0.0001704149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957792,0.001445446,0.0001649239,0.001395156,0.000140785,0.0003491016,0.00001750202,0.00001103989,0.0006968849],"genre_scores_gemma":[0.9972348,0.0003541618,0.0004632589,0.0006491199,0.0001777771,0.00003196815,0.00003165363,0.00001696257,0.001040304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0362723,"threshold_uncertainty_score":0.5095413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145397641671311,"score_gpt":0.3048559351610278,"score_spread":0.2903161709938967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}