{"id":"W1999564272","doi":"10.1097/cad.0b013e3283287c20","title":"Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777","year":2009,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Prodrug; Pharmacokinetics; Pharmacology; Nicotinamide; Bolus (digestion); Therapeutic index; Chemistry; Mechanism of action; Medicine; In vitro; Drug; Internal medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004628435,0.0006696171,0.0006473366,0.0003288776,0.0002209672,0.0004418169,0.000728979,0.0006091413,0.002341107],"category_scores_gemma":[0.0002663009,0.0002495559,0.0003095799,0.0002372346,0.0002798204,0.0003705257,0.0002292336,0.001477783,0.0006888512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005698501,"about_ca_system_score_gemma":0.0008748819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016859,"about_ca_topic_score_gemma":0.0018512,"domain_scores_codex":[0.9998821,0.00002443796,0.00000575429,0.00001684796,0.00003121644,0.00003966895],"domain_scores_gemma":[0.9998704,0.00001465028,0.00002555751,0.00001347681,0.00002680367,0.00004910729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003075658,0.005363506,0.0006332886,0.0003618549,0.0001083589,0.0003294174,0.0001076857,0.004300063,0.9495984,0.001001197,0.001862415,0.03325811],"study_design_scores_gemma":[0.002814126,0.1188749,0.004194731,0.00008085524,0.000311486,0.0007809613,0.000118619,0.00505327,0.8396927,0.0005503701,0.02750262,0.00002541274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977047,0.00446721,0.007576786,0.0004139541,0.0001509607,0.00160369,0.001940808,0.0002842996,0.006515279],"genre_scores_gemma":[0.9762464,0.006611061,0.005617866,0.0002550026,0.00005844886,0.001115037,0.0031819,0.00004668739,0.006867506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002341107,"threshold_uncertainty_score":0.007831812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145397641671311,"score_gpt":0.3048559351610278,"score_spread":0.2903161709938967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}