{"id":"W1999595668","doi":"10.1038/sj.mt.6300383","title":"Inducible Packaging Cells for Large-scale Production of Lentiviral Vectors in Serum-free Suspension Culture","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; National Research Council Canada; Université de Montréal; Institut National de la Recherche Scientifique","funders":"","keywords":"Vesicular stomatitis virus; Transfection; Cell culture; Bioreactor; Viral vector; Molecular biology; Biology; Virology; Recombinant DNA; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001462788,0.001082367,0.001146786,0.001198819,0.000565196,0.001285102,0.001672662,0.0008294667,0.003520742],"category_scores_gemma":[0.0008948445,0.0006720428,0.0007136926,0.001309447,0.000428483,0.0006274362,0.0006660491,0.002913519,0.00433318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005259281,"about_ca_system_score_gemma":0.0006832005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007056294,"about_ca_topic_score_gemma":0.001386174,"domain_scores_codex":[0.9990174,0.0001698613,0.0001763613,0.0001564962,0.0003656073,0.0001142659],"domain_scores_gemma":[0.9994537,0.0001872703,0.00006836708,0.000138985,0.00008104883,0.00007058237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007013478,0.00009738829,0.00008733202,0.00008939648,0.0000107318,0.00005728985,0.00006031156,0.0000918346,0.9939819,0.0007886658,0.0005411147,0.00412384],"study_design_scores_gemma":[0.00004528437,0.000126494,0.0004778653,0.00001690719,0.00003915251,0.0001660392,0.00001338579,0.00164047,0.9869543,0.0001952506,0.01031365,0.00001116283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2121712,0.003795992,0.7481046,0.0004568248,0.001092736,0.004370673,0.01296669,0.004745682,0.01229574],"genre_scores_gemma":[0.3772684,0.005464917,0.5394022,0.0003278683,0.0003446808,0.004449793,0.03962949,0.002118383,0.03099423],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003520742,"threshold_uncertainty_score":0.01177812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02030249794805705,"score_gpt":0.2817669171856024,"score_spread":0.2614644192375454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}