{"id":"W1999596958","doi":"10.1038/nbt813","title":"Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype","year":2003,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; Agence Nationale pour la Gestion des Déchets Radioactifs","keywords":"Phenotype; Transgene; RNA interference; Biology; Embryo; Genetics; RNA; Cell biology; Null (SQL); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004561446,0.00123465,0.0006435874,0.001121938,0.0004485736,0.000800047,0.001185355,0.001204011,0.002723841],"category_scores_gemma":[0.0003151051,0.0007391643,0.0008022518,0.000421516,0.001074392,0.0005137204,0.0006174284,0.002361429,0.00273154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007729204,"about_ca_system_score_gemma":0.0004641653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001395351,"about_ca_topic_score_gemma":0.002159988,"domain_scores_codex":[0.999405,0.00005763342,0.00009086624,0.0001318845,0.0002335013,0.00008108353],"domain_scores_gemma":[0.9991162,0.0002260195,0.0002643971,0.000159165,0.00006659547,0.0001675338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002267844,0.000009575787,0.00003269493,0.000009989505,0.000003730801,0.00009968867,0.000007341772,0.00006625104,0.9992618,0.0001951225,0.00003741974,0.0002537689],"study_design_scores_gemma":[0.00001135567,0.0000316448,0.000559052,0.000003245576,0.00001339981,0.0002434806,0.00000955156,0.0006455144,0.9967308,0.00005926681,0.001687936,0.000004744698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9123386,0.001767979,0.06248187,0.000972915,0.0007356204,0.0002371134,0.00419613,0.002929067,0.01434065],"genre_scores_gemma":[0.9472656,0.001378323,0.02145192,0.0003250406,0.00008929415,0.0001576844,0.002377686,0.001280072,0.02567429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002723841,"threshold_uncertainty_score":0.009112179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005406051432143294,"score_gpt":0.2227641753488035,"score_spread":0.2173581239166602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}