{"id":"W1999596958","doi":"10.1038/nbt813","title":"Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype","year":2003,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; Agence Nationale pour la Gestion des Déchets Radioactifs","keywords":"Phenotype; Transgene; RNA interference; Biology; Embryo; Genetics; RNA; Cell biology; Null (SQL); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000107941,0.0002831939,0.0002616889,0.0002106358,0.0000486732,0.00001836968,0.0004973705,0.001850791,0.00009169033],"category_scores_gemma":[0.00011904,0.0002699773,0.0001103533,0.0002745778,0.0001633583,0.000005128,0.00008061121,0.0007687146,0.00005513476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000255947,"about_ca_system_score_gemma":0.00009841349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000198147,"about_ca_topic_score_gemma":0.0002273623,"domain_scores_codex":[0.9984075,0.00008805557,0.0003030343,0.0006673103,0.00008533031,0.0004487529],"domain_scores_gemma":[0.9991863,0.00001403481,0.00008535154,0.000588488,0.00006732265,0.00005843763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008875096,0.00008654135,0.0005525186,0.00001820985,0.00003005311,0.00001398281,0.00005323269,0.00002393184,0.9940738,0.0003798733,0.0003762794,0.004302832],"study_design_scores_gemma":[0.0006188487,0.0005027801,0.001029884,0.00002432813,0.00001518365,0.00002419573,0.0001310537,0.00002184039,0.988288,0.000697875,0.008328074,0.0003179377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873493,0.009423,0.001123968,0.0003773604,0.0003851316,0.0002245436,0.000009952024,0.00005001009,0.001056708],"genre_scores_gemma":[0.9953229,0.002061869,0.001767352,0.0004100715,0.00005706552,0.00002746764,0.0000271459,0.00003028041,0.0002958142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007973608,"threshold_uncertainty_score":0.9999753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005406051432143294,"score_gpt":0.2227641753488035,"score_spread":0.2173581239166602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}