{"id":"W1999601929","doi":"10.1074/jbc.m114.552562","title":"After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Antiparallel (mathematics); Bcl-2-associated X protein; Helix (gastropod); Biophysics; Bcl-xL; Cytosol; Biology; Cell biology; Chemistry; Crystallography; Apoptosis; Biochemistry; Programmed cell death; Physics; Caspase 3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001350752,0.0003893117,0.0001806029,0.0001318985,0.0002562052,0.0002604056,0.000302351,0.0002992318,0.002889753],"category_scores_gemma":[0.0001109322,0.0002641721,0.0002535994,0.000141563,0.0001513026,0.0003170019,0.0002362696,0.0007734074,0.001003904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457516,"about_ca_system_score_gemma":0.0001974592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610185,"about_ca_topic_score_gemma":0.0004946155,"domain_scores_codex":[0.9998473,0.00001664103,0.000007507669,0.00004125298,0.00004555892,0.00004180395],"domain_scores_gemma":[0.9999028,0.00002088479,0.00002599056,0.00001634817,0.00001322458,0.00002065321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006950744,0.00002655676,0.00008801198,0.00002473736,0.000005920248,0.00003561266,0.00001991099,0.0001069219,0.9985191,0.0002055006,0.00004313655,0.0008550723],"study_design_scores_gemma":[0.00002463643,0.000166904,0.001371933,0.000009368483,0.00001599786,0.0001216949,0.00002944231,0.002691964,0.9910132,0.0001604439,0.004389714,0.000004656287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835398,0.00102434,0.01230094,0.0001606907,0.00009766491,0.00006365804,0.0002519257,0.0001822661,0.002378745],"genre_scores_gemma":[0.9754964,0.001090502,0.01476902,0.00009168457,0.00002188862,0.0001394001,0.001110078,0.0000830889,0.00719796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002889753,"threshold_uncertainty_score":0.009667158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009260122439533358,"score_gpt":0.2304993462072167,"score_spread":0.2212392237676833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}