{"id":"W1999605403","doi":"10.1038/nsmb886","title":"Specific and potent RNAi in the nucleus of human cells","year":2005,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Ontario HIV Treatment Network","keywords":"RNA interference; Gene knockdown; Small interfering RNA; Cell biology; Gene silencing; RNA; Trans-acting siRNA; Cytoplasm; Nucleus; Biology; microRNA; Gene expression; RNA silencing; Molecular biology; Gene; Chemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002834528,0.0002606798,0.0003505933,0.000281689,0.0002314338,0.0005496238,0.0001933153,0.0002852178,0.001481253],"category_scores_gemma":[0.0001566556,0.0002078847,0.0002531127,0.0001383018,0.0002714006,0.0002559554,0.0002938706,0.0004658159,0.001115611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004351083,"about_ca_system_score_gemma":0.0006417625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001462031,"about_ca_topic_score_gemma":0.002204889,"domain_scores_codex":[0.9998134,0.00002893225,0.00001253769,0.00006060196,0.00005203133,0.00003250648],"domain_scores_gemma":[0.99989,0.00002671286,0.00001411931,0.00002285654,0.00002805267,0.00001832951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007222786,0.00001049165,0.000124809,0.00003352478,0.00000533515,0.00007048544,0.00004268289,0.00005720013,0.9957243,0.0007328393,0.000206638,0.002919506],"study_design_scores_gemma":[0.00001993684,0.0001126371,0.001076679,0.000006881492,0.00001488861,0.00032443,0.00003056051,0.0003632158,0.9896813,0.0002263942,0.008139326,0.000003690169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8754618,0.02751335,0.06357037,0.001251079,0.000311903,0.0001635228,0.001848384,0.001318154,0.0285615],"genre_scores_gemma":[0.9707296,0.003668146,0.009515517,0.0001861696,0.00003770172,0.00004961406,0.001397655,0.000147719,0.01426775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481253,"threshold_uncertainty_score":0.004955351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00464233785766031,"score_gpt":0.2776929658104042,"score_spread":0.2730506279527439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}