{"id":"W1999673371","doi":"10.1038/tpj.2009.65","title":"Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant","year":2009,"lang":"en","type":"review","venue":"The Pharmacogenomics Journal","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Case Western Reserve University","keywords":"Allele; Pharmacogenetics; Genetics; Meta-analysis; Single-nucleotide polymorphism; Clozapine; Population; Dopamine receptor D3; Biology; Haplotype; Polymorphism (computer science); Gene; Oncology; Dopamine receptor D2; Genotype; Internal medicine; Medicine; Receptor; Schizophrenia (object-oriented programming); Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0043309,0.001818961,0.007612325,0.001407454,0.0002780291,0.001179272,0.001381342,0.001157507,0.00179163],"category_scores_gemma":[0.006472446,0.0008368942,0.01705775,0.002503554,0.0002826314,0.0005313106,0.0006135839,0.001060318,0.0001648112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008582887,"about_ca_system_score_gemma":0.001161049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004768829,"about_ca_topic_score_gemma":0.0113658,"domain_scores_codex":[0.9978544,0.001079172,0.0003952548,0.000352046,0.0002301378,0.0000889306],"domain_scores_gemma":[0.9957717,0.003286336,0.0004971109,0.0001715933,0.0001977874,0.00007540961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.01187048,0.00007556993,0.022674,0.03061555,0.8959231,0.0003853697,0.00007654003,0.001399664,0.001355672,0.0001185029,0.0007982708,0.03470718],"study_design_scores_gemma":[0.001402946,0.0005336669,0.02220619,0.0009684103,0.9716149,0.0002801114,0.00005230846,0.0004974328,0.0003721571,0.0002253415,0.001812901,0.00003360803],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06106677,0.9366065,0.001071205,0.0002168854,0.0001590217,0.00005759005,0.000515129,0.00004107141,0.0002659282],"genre_scores_gemma":[0.634317,0.3600572,0.003196151,0.0004136009,0.0001793375,0.0001055993,0.001198139,0.00003616828,0.0004967255],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007612325,"threshold_uncertainty_score":0.02290428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08189236670396624,"score_gpt":0.37449762211691,"score_spread":0.2926052554129437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}