{"id":"W1999683656","doi":"10.1210/en.2005-0523","title":"Posttranslational, Reversible O-Glycosylation Is Stimulated by High Glucose and Mediates Plasminogen Activator Inhibitor-1 Gene Expression and Sp1 Transcriptional Activity in Glomerular Mesangial Cells","year":2005,"lang":"en","type":"article","venue":"Endocrinology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Diabetes Canada; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Gene expression; Activator (genetics); Molecular biology; Gene knockdown; Biology; Regulation of gene expression; Glycosylation; Plasminogen activator inhibitor-1; Messenger RNA; Plasminogen activator; Chemistry; Gene; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001015741,0.000195374,0.0001901239,0.0001524416,0.0001081135,0.00002359116,0.00009182879,0.0002343657,0.0001909036],"category_scores_gemma":[0.00003164069,0.0002014947,0.00004047444,0.0001126088,0.0001237569,0.00003845571,0.00006892787,0.0001923489,0.00001225787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003482348,"about_ca_system_score_gemma":0.00006087523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000099139,"about_ca_topic_score_gemma":0.00005184234,"domain_scores_codex":[0.9985842,0.0001255193,0.0002224452,0.0004938847,0.0002155287,0.0003584728],"domain_scores_gemma":[0.9995505,0.00004025858,0.0000631043,0.0001635352,0.00006162914,0.0001209785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005407466,0.0001082969,0.003282201,0.00001581093,0.00002753356,0.000005680039,0.00009217784,0.0001260763,0.9920277,0.00003130735,0.0007294485,0.003012994],"study_design_scores_gemma":[0.002464117,0.0001788604,0.01331297,0.000009193696,0.000008626314,0.00001995914,0.00001300866,0.0005181847,0.9685965,0.00006141498,0.01462171,0.0001954576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957941,0.002028166,0.0003845553,0.001148844,0.00007493376,0.0003336963,0.0001734071,0.00001654812,0.00004578119],"genre_scores_gemma":[0.9966885,0.001036582,0.001436495,0.0001380693,0.0001420927,0.00002668698,0.0003028093,0.00002011604,0.0002086576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02343123,"threshold_uncertainty_score":0.8216713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057328302956551,"score_gpt":0.2501497729133942,"score_spread":0.2395764898838287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}