{"id":"W1999683656","doi":"10.1210/en.2005-0523","title":"Posttranslational, Reversible O-Glycosylation Is Stimulated by High Glucose and Mediates Plasminogen Activator Inhibitor-1 Gene Expression and Sp1 Transcriptional Activity in Glomerular Mesangial Cells","year":2005,"lang":"en","type":"article","venue":"Endocrinology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Diabetes Canada; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Gene expression; Activator (genetics); Molecular biology; Gene knockdown; Biology; Regulation of gene expression; Glycosylation; Plasminogen activator inhibitor-1; Messenger RNA; Plasminogen activator; Chemistry; Gene; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254985,0.0003411768,0.0003116291,0.0002069575,0.0001488467,0.0003295439,0.0001630883,0.0002099265,0.0009012462],"category_scores_gemma":[0.00009104126,0.0001882808,0.0003250551,0.000171972,0.0002304008,0.0001914789,0.000206924,0.0007461591,0.0003610729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196939,"about_ca_system_score_gemma":0.0001599581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007777416,"about_ca_topic_score_gemma":0.0009154485,"domain_scores_codex":[0.999823,0.00002745994,0.00001085819,0.00004061161,0.00004924284,0.00004888312],"domain_scores_gemma":[0.9999119,0.00001204711,0.00001925468,0.00001137728,0.00001354074,0.00003171117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001009051,0.00002104664,0.0002065117,0.00003166926,0.000003764164,0.00003179955,0.00001289982,0.00002079636,0.998558,0.00004503772,0.00003515515,0.0009323351],"study_design_scores_gemma":[0.00003671983,0.0003173301,0.02807811,0.000008893369,0.0000221513,0.0003283237,0.00008543438,0.001215251,0.9674941,0.0001055741,0.002298562,0.000009653385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920803,0.003727087,0.002239876,0.0001497401,0.00004405369,0.00002140459,0.0003389277,0.00006775308,0.001330914],"genre_scores_gemma":[0.9939938,0.00162114,0.001457246,0.00008065527,0.00003311734,0.00003145847,0.000634036,0.00001358596,0.002135049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009012462,"threshold_uncertainty_score":0.003014982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057328302956551,"score_gpt":0.2501497729133942,"score_spread":0.2395764898838287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}