{"id":"W1999722013","doi":"10.1021/bi8010785","title":"Structural Analysis of Golgi α-Mannosidase II Inhibitors Identified from a Focused Glycosidase Inhibitor Screen","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources","keywords":"Mannosidase; Glycoside hydrolase; Golgi apparatus; Iminosugar; Chemistry; Biochemistry; Enzyme; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376965,0.0007326039,0.0006938596,0.0006027785,0.000170495,0.0004369904,0.0004961033,0.0002816479,0.001592074],"category_scores_gemma":[0.0002498695,0.000241167,0.0004867947,0.0006783753,0.0001242466,0.0001830678,0.0001751464,0.0004929378,0.0005021488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004467844,"about_ca_system_score_gemma":0.0003279271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001989669,"about_ca_topic_score_gemma":0.002588447,"domain_scores_codex":[0.999874,0.00001156988,0.00001123442,0.00002339155,0.00005873203,0.000021061],"domain_scores_gemma":[0.9998717,0.00002281092,0.00002779611,0.000009668853,0.00004192619,0.00002599208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003123826,0.0001951063,0.001222669,0.0001580256,0.00008436394,0.0002899655,0.00004078519,0.00506597,0.9828788,0.0001295242,0.0003436009,0.009278848],"study_design_scores_gemma":[0.0001370283,0.002624543,0.009239976,0.00002750982,0.0003395758,0.001124744,0.0000777392,0.008643943,0.9716503,0.00007406051,0.006024744,0.00003582152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980996,0.005116951,0.004905644,0.0001612405,0.00001960819,0.0001958926,0.004407345,0.0002108487,0.003986376],"genre_scores_gemma":[0.9705123,0.005828773,0.006702632,0.0001476638,0.00001037979,0.00008687427,0.01326668,0.0000663609,0.003378395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001989669,"threshold_uncertainty_score":0.005326033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01707246354524756,"score_gpt":0.2621379491961289,"score_spread":0.2450654856508813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}