{"id":"W1999787047","doi":"10.1038/cdd.2009.164","title":"NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response","year":2009,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Internal ribosome entry site; Translation (biology); Cell biology; Biology; Unfolded protein response; RNA-binding protein; Protein biosynthesis; Endoplasmic reticulum; Messenger RNA; Untranslated region; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004076372,0.0006533636,0.0004339108,0.0004420004,0.0007489649,0.001019529,0.0002666052,0.0003717485,0.0008205824],"category_scores_gemma":[0.0004761386,0.0003070997,0.0005235446,0.0001985557,0.0004466978,0.0008096779,0.0004904594,0.0006836352,0.0006177291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001592457,"about_ca_system_score_gemma":0.0005370895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186334,"about_ca_topic_score_gemma":0.001491897,"domain_scores_codex":[0.9996204,0.00003546563,0.00003206881,0.0001160385,0.0001042405,0.00009172584],"domain_scores_gemma":[0.999632,0.00003174563,0.00009080926,0.00005287989,0.00007237812,0.0001201984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212735,0.00001309657,0.0005876874,0.00002735961,0.000005518858,0.00009589745,0.00002887305,0.00005511141,0.996999,0.0004610115,0.0001080568,0.00149722],"study_design_scores_gemma":[0.000008831662,0.00003549601,0.005479794,0.000005968164,0.00001004436,0.0003378586,0.00003695989,0.001623643,0.9893264,0.0002587869,0.002866997,0.000009210121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704146,0.00532719,0.01900576,0.0002745413,0.000277176,0.00003385915,0.0005401553,0.0006033769,0.003523295],"genre_scores_gemma":[0.9910158,0.0006130232,0.005199724,0.00005650257,0.00002911744,0.00001798344,0.0006459224,0.0000804121,0.002341568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592457,"threshold_uncertainty_score":0.01155412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756552029629675,"score_gpt":0.2518638200913396,"score_spread":0.2242982997950429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}