{"id":"W1999787047","doi":"10.1038/cdd.2009.164","title":"NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response","year":2009,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Internal ribosome entry site; Translation (biology); Cell biology; Biology; Unfolded protein response; RNA-binding protein; Protein biosynthesis; Endoplasmic reticulum; Messenger RNA; Untranslated region; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290963,0.000111026,0.00009858399,0.0000354413,0.000189994,0.00003281141,0.00006374189,0.0001129322,0.00001921301],"category_scores_gemma":[0.00002779432,0.0000867144,0.00007492243,0.00003331806,0.00001311963,0.00001589283,0.000004450402,0.0000307886,4.141818e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005641774,"about_ca_system_score_gemma":0.00002061952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007389229,"about_ca_topic_score_gemma":0.000005451639,"domain_scores_codex":[0.999322,0.00009923776,0.0001539236,0.0002059169,0.00008991503,0.0001290077],"domain_scores_gemma":[0.9996218,0.00002479321,0.0001029334,0.0001685026,0.00003764123,0.0000443436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001134553,0.00004161727,0.0001953663,0.0000319938,0.00001287741,9.056107e-8,0.000391532,0.000002242474,0.9820509,0.00002662721,0.000002838997,0.01610939],"study_design_scores_gemma":[0.0006287775,0.0004461136,0.02150791,0.00001646524,0.00003414667,9.462922e-7,0.0001384886,0.0001240282,0.9759315,0.0007286701,0.0003384794,0.0001044383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748765,0.0002596955,0.02392152,0.0001873923,0.00003935702,0.0005801861,0.00003397691,0.00001163016,0.00008974161],"genre_scores_gemma":[0.998919,0.00004068918,0.0003676739,0.00003953,0.00005540977,0.00004673465,0.0000725827,0.00001067135,0.0004477087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0240425,"threshold_uncertainty_score":0.3536111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756552029629675,"score_gpt":0.2518638200913396,"score_spread":0.2242982997950429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}