{"id":"W1999791612","doi":"10.1016/j.bbrc.2014.04.071","title":"Down regulation of brain cellular prion protein in an animal model of insulin resistance: Possible implication in increased prevalence of stroke in pre-diabetics/diabetics","year":2014,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Neuroprotection; Insulin resistance; Internal medicine; Endocrinology; Excitotoxicity; Glutamate receptor; Medicine; Insulin; Stroke (engine); NMDA receptor; Prediabetes; Diabetes mellitus; Protein kinase B; Fructose; Insulin receptor; Type 2 diabetes; Phosphorylation; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819772,0.0003751813,0.0002621161,0.0009393091,0.0002461861,0.0003831358,0.0002162544,0.0003888895,0.001525215],"category_scores_gemma":[0.0002123195,0.0001757881,0.0002404536,0.0003906551,0.0003720685,0.0002458369,0.0001684845,0.0005733717,0.0002169038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524835,"about_ca_system_score_gemma":0.00008681747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003668402,"about_ca_topic_score_gemma":0.0002905315,"domain_scores_codex":[0.9998806,0.00002899817,0.00001413959,0.00003569463,0.00001984039,0.00002074217],"domain_scores_gemma":[0.9997172,0.00003567652,0.0001017977,0.00003896391,0.00002255385,0.00008383081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003121943,0.0002913282,0.003344945,0.00005573321,0.00003057507,0.0004564996,0.00005828154,0.00004133746,0.9903376,0.0001547424,0.00004420071,0.002062908],"study_design_scores_gemma":[0.0002712139,0.007062766,0.166553,0.00003389606,0.0004397428,0.003505134,0.0004565845,0.002296231,0.8160548,0.0007448365,0.002537552,0.00004418474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985849,0.0003208739,0.000571488,0.00003461518,0.00001487012,0.000007799636,0.0001490303,0.00001803771,0.000298423],"genre_scores_gemma":[0.9977129,0.000471785,0.0006678861,0.00002967775,0.000008527149,0.00001975368,0.0002360682,0.00001391364,0.0008395924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525215,"threshold_uncertainty_score":0.005102396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02976310397299153,"score_gpt":0.3271603504271475,"score_spread":0.2973972464541559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}