{"id":"W1999796332","doi":"10.1210/en.2005-1426","title":"DHCR24-Knockout Embryonic Fibroblasts Are Susceptible to Serum Withdrawal-Induced Apoptosis Because of Dysfunction of Caveolae and Insulin-Akt-Bad Signaling","year":2006,"lang":"en","type":"article","venue":"Endocrinology","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Caveolae; Biology; Protein kinase B; Internal medicine; Endocrinology; Cell biology; Cholesterol; Lipid raft; Insulin; Insulin receptor; Signal transduction; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001530383,0.0005488354,0.0003715737,0.0005038293,0.000250424,0.0003700871,0.0003665658,0.00047799,0.001853128],"category_scores_gemma":[0.0001364527,0.0003036339,0.0005031406,0.000313357,0.0002853677,0.000242125,0.0002896697,0.0007773379,0.0007610755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003104986,"about_ca_system_score_gemma":0.0002042838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001385413,"about_ca_topic_score_gemma":0.00140663,"domain_scores_codex":[0.999737,0.00001748161,0.00004547216,0.00007124547,0.00007811669,0.00005070122],"domain_scores_gemma":[0.9997944,0.00001908501,0.00006784451,0.000032613,0.00002006232,0.00006604488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001193813,0.00001375008,0.0002550225,0.00002506549,0.00001034881,0.0002186102,0.00001294316,0.00003194441,0.9985359,0.00007667883,0.00004331132,0.0006570633],"study_design_scores_gemma":[0.00005766,0.000154837,0.014472,0.00001161168,0.00005339329,0.001654049,0.00006662212,0.0009894698,0.9780864,0.0001059849,0.004331905,0.00001603364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890358,0.00212885,0.003666573,0.0001782251,0.00008634885,0.00005040599,0.003153873,0.0002055422,0.001494382],"genre_scores_gemma":[0.9872917,0.001397308,0.002547994,0.00009371901,0.00001524058,0.000100321,0.002554584,0.00005867146,0.005940548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001853128,"threshold_uncertainty_score":0.00619936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006616945404144121,"score_gpt":0.2184116567770433,"score_spread":0.2117947113728992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}