{"id":"W1999856629","doi":"10.1523/jneurosci.3348-08.2008","title":"Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist","year":2008,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":264,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Douglas College; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Alzheimer Society","keywords":"Pioglitazone; Internal medicine; Oxidative stress; Endocrinology; Cholinergic; Agonist; Neuroscience; Morris water navigation task; Medicine; Chemistry; Pharmacology; Receptor; Hippocampus; Biology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002068743,0.0008872996,0.0006868342,0.0006003003,0.0002642464,0.0003715576,0.0005247444,0.0005959021,0.0008922087],"category_scores_gemma":[0.0001632248,0.0003145135,0.0004152417,0.0002969996,0.0003273252,0.0003338308,0.0002333098,0.0009570066,0.0003539753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002447428,"about_ca_system_score_gemma":0.0005029107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265787,"about_ca_topic_score_gemma":0.001888126,"domain_scores_codex":[0.9998143,0.0000163499,0.00003185119,0.00004316854,0.00004068468,0.0000536986],"domain_scores_gemma":[0.9997652,0.00001405598,0.00009026983,0.00004136494,0.00002651001,0.00006266658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006049158,0.0001734921,0.0001062102,0.00005129351,0.00001906822,0.0001415777,0.00002846665,0.00008071696,0.9956813,0.0001298375,0.00006233339,0.002920755],"study_design_scores_gemma":[0.0002116352,0.002384771,0.004836524,0.00002296913,0.0000908691,0.0004828066,0.00004633763,0.0006954052,0.9870356,0.0002180668,0.003958324,0.00001676548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907631,0.002276875,0.004082347,0.0001385383,0.00009071589,0.00009567181,0.0009576725,0.000401236,0.001193851],"genre_scores_gemma":[0.9790239,0.0048313,0.006823704,0.0001634108,0.0000779891,0.0004332337,0.001658773,0.0001089404,0.006878656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265787,"threshold_uncertainty_score":0.002984762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04235776565461409,"score_gpt":0.2860381653439188,"score_spread":0.2436803996893048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}