{"id":"W1999899858","doi":"10.1021/cb500249j","title":"Versatile Cardiac Troponin Chimera for Muscle Protein Structural Biology and Drug Discovery","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Drug discovery; Chimera (genetics); Structural biology; Cardiac muscle; Troponin; Computational biology; Biology; Cell biology; Bioinformatics; Biochemistry; Anatomy; Medicine; Cardiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004624036,0.0003509597,0.0002992695,0.0002393806,0.0002472272,0.0003675293,0.0006379642,0.000559456,0.001042518],"category_scores_gemma":[0.0002395889,0.0002198561,0.0003634783,0.0002577699,0.0002488877,0.0002785173,0.0003647158,0.001051283,0.0003905979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005259672,"about_ca_system_score_gemma":0.0003310687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005885146,"about_ca_topic_score_gemma":0.0007886649,"domain_scores_codex":[0.9997895,0.00004071965,0.00001583463,0.00005165208,0.00007601855,0.00002616682],"domain_scores_gemma":[0.9998813,0.0000183538,0.00002874036,0.00002189425,0.00001336999,0.00003639135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095586,0.00003389948,0.00009157671,0.00003623803,0.0000116102,0.00004966524,0.00001782327,0.0003207643,0.9954117,0.001074109,0.0001348609,0.002708333],"study_design_scores_gemma":[0.00005867251,0.0002395169,0.0005815281,0.00001438242,0.00004093842,0.000539079,0.00001192353,0.003632837,0.9715374,0.0001839084,0.02314441,0.00001551727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8430379,0.005385779,0.1397369,0.0006806932,0.0002142209,0.0003691601,0.002037664,0.001108581,0.007429101],"genre_scores_gemma":[0.884794,0.002782634,0.1035865,0.0002364043,0.00002087678,0.0002428406,0.003026019,0.0002004723,0.005110324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042518,"threshold_uncertainty_score":0.003816187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00786547260465304,"score_gpt":0.2650700891041838,"score_spread":0.2572046164995307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}