{"id":"W1999899858","doi":"10.1021/cb500249j","title":"Versatile Cardiac Troponin Chimera for Muscle Protein Structural Biology and Drug Discovery","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Drug discovery; Chimera (genetics); Structural biology; Cardiac muscle; Troponin; Computational biology; Biology; Cell biology; Bioinformatics; Biochemistry; Anatomy; Medicine; Cardiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502196,0.000161591,0.0005086601,0.00003326639,0.00006972734,0.000007888922,0.0000605122,0.0001539615,0.000006478042],"category_scores_gemma":[0.0003452841,0.0001178436,0.0001331911,0.00004873105,0.0003721349,0.00003626649,0.0001154211,0.0001377198,0.000003729624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000265764,"about_ca_system_score_gemma":0.00002002536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004279764,"about_ca_topic_score_gemma":0.0000012662,"domain_scores_codex":[0.9990631,0.00006062236,0.0001782453,0.0003555767,0.00003556318,0.0003069337],"domain_scores_gemma":[0.9994093,0.000232677,0.00004979391,0.0001905093,0.00004267349,0.00007502243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002483726,0.00001287947,0.007065524,0.0000457989,0.0001217488,5.773648e-7,0.0001422724,3.105986e-8,0.9697241,0.005936184,0.0007985553,0.01590392],"study_design_scores_gemma":[0.005113213,0.0009270491,0.02091756,0.00005537902,0.0003648059,0.00003413299,0.0002933708,0.00003907231,0.8356578,0.01109206,0.1249575,0.0005480915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962985,0.0009624481,0.0001513082,0.001201555,0.0002514147,0.0004870258,0.00009304444,0.0000424369,0.0005122798],"genre_scores_gemma":[0.9977478,0.00004317811,0.0008021343,0.0002967199,0.0006292132,0.0001151408,0.0001950476,0.00001351837,0.0001572009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1340664,"threshold_uncertainty_score":0.4805522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00786547260465304,"score_gpt":0.2650700891041838,"score_spread":0.2572046164995307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}