{"id":"W1999939143","doi":"10.1021/ac050342t","title":"DNA-Driven Focusing for Protein−DNA Binding Assays Using Capillary Electrophoresis","year":2005,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; National Institutes of Natural Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Aptamer; DNA; Capillary electrophoresis; Nucleic acid; Oligonucleotide; Molecular biology; Gel electrophoresis; Affinity electrophoresis; Biochemistry; Chromatography; Affinity chromatography; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002253958,0.002322686,0.001466212,0.001838187,0.0006483736,0.0008075494,0.002770785,0.001830162,0.00169007],"category_scores_gemma":[0.00225427,0.001042817,0.0006209988,0.0009762006,0.0006926387,0.0008048747,0.0007499526,0.002939423,0.001302807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008089464,"about_ca_system_score_gemma":0.0007045795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000929377,"about_ca_topic_score_gemma":0.001493942,"domain_scores_codex":[0.9975423,0.0006088491,0.000131688,0.0004314294,0.001095513,0.0001903782],"domain_scores_gemma":[0.9978349,0.001114822,0.0001952611,0.0001779681,0.0005389379,0.0001381143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004235909,0.00005137538,0.00007437726,0.0002266101,0.00002379949,0.00005541357,0.00003300261,0.0001459743,0.9887465,0.000519553,0.0005277144,0.009553401],"study_design_scores_gemma":[0.00002317752,0.0001817437,0.0004253715,0.00002229126,0.00003156655,0.0005192687,0.000009397058,0.004967096,0.9862061,0.0003093406,0.00724081,0.00006375864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.05712623,0.009149533,0.924738,0.0003441119,0.0004850805,0.001056887,0.00056531,0.004183065,0.002351828],"genre_scores_gemma":[0.1071651,0.007249256,0.8778883,0.0004539894,0.0001618766,0.002283172,0.001376183,0.0002037351,0.003218469],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002770785,"threshold_uncertainty_score":0.01192027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459741591914943,"score_gpt":0.2845396432599925,"score_spread":0.2699422273408431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}