{"id":"W1999952543","doi":"10.1038/nn.3318","title":"Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways","year":2013,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":1436,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"York University","keywords":"Microglia; IRF8; Biology; Cell biology; Transcription factor; Yolk sac; Population; Downregulation and upregulation; Immunology; Medicine; Genetics; Inflammation; Gene; Embryo","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003145027,0.0004376178,0.0002973911,0.0004549838,0.0003336717,0.0006429398,0.0002545767,0.0004508948,0.002628164],"category_scores_gemma":[0.000316373,0.0002225158,0.0003547277,0.000117278,0.000201956,0.0006018884,0.0006888374,0.001362213,0.001333424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551273,"about_ca_system_score_gemma":0.0001888951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001655197,"about_ca_topic_score_gemma":0.0004996377,"domain_scores_codex":[0.9996362,0.00006211203,0.00002211144,0.00004870865,0.00008090398,0.0001499381],"domain_scores_gemma":[0.9997812,0.00002718696,0.00006466938,0.00002820216,0.00005092187,0.00004781454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000402143,0.00005432261,0.001686321,0.00009043107,0.00001287975,0.0004757293,0.0001304049,0.00008034841,0.9831172,0.001815414,0.0004623639,0.01167242],"study_design_scores_gemma":[0.0001232097,0.0004684026,0.04308947,0.000116195,0.00005907052,0.002829298,0.0006698213,0.002193895,0.926662,0.002902835,0.02085921,0.0000265936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691325,0.00501714,0.01334582,0.0006170267,0.0001460059,0.00007692042,0.0004978265,0.0002839913,0.0108826],"genre_scores_gemma":[0.9821878,0.001377138,0.006614509,0.0001672492,0.00008921658,0.00009413304,0.0004287449,0.00005528827,0.008985923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002628164,"threshold_uncertainty_score":0.008792102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656482733450098,"score_gpt":0.2309734198992653,"score_spread":0.2144085925647644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}