{"id":"W1999979510","doi":"10.1128/cmr.00117-14","title":"The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria","year":2015,"lang":"en","type":"review","venue":"Clinical Microbiology Reviews","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1570,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Efflux; Antibiotics; Biology; Bacteria; Antibiotic resistance; Multiple drug resistance; Microbiology; Drug resistance; Plasmid; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006631795,0.0007732891,0.001106435,0.002039775,0.0003337493,0.001067263,0.0007298423,0.001178173,0.002552187],"category_scores_gemma":[0.0007497894,0.0002857393,0.0003722338,0.002009949,0.0006241819,0.001591443,0.0008408272,0.001913355,0.002563156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006993452,"about_ca_system_score_gemma":0.001103059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000778738,"about_ca_topic_score_gemma":0.001124006,"domain_scores_codex":[0.9997217,0.00004584984,0.00003450138,0.00004440436,0.0001223697,0.00003119194],"domain_scores_gemma":[0.9996038,0.0001520316,0.00005025028,0.00001493874,0.0001263801,0.00005257594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005428983,0.0000594255,0.0001536396,0.01543861,0.00004728046,0.0002140194,0.0000846563,0.0003519124,0.005954755,0.00714134,0.03106192,0.9394383],"study_design_scores_gemma":[0.000005425501,0.00006090867,0.0004720638,0.001625856,0.00003435988,0.0008065218,0.00004561749,0.00005142699,0.0007546439,0.001644533,0.9944847,0.00001394874],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001017849,0.9985586,0.0001454765,0.0002332332,0.0001876793,0.000002147957,0.000007521368,0.000008397961,0.0007552031],"genre_scores_gemma":[0.0005408851,0.9984611,0.0001900501,0.0001458891,0.0001340951,0.00000303263,0.00001329123,0.000001713446,0.0005100484],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002552187,"threshold_uncertainty_score":0.008537889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0863130964741443,"score_gpt":0.3978705549734406,"score_spread":0.3115574584992963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}