{"id":"W2000017891","doi":"10.1016/j.virusres.2012.06.002","title":"Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir","year":2012,"lang":"en","type":"article","venue":"Virus Research","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse","keywords":"Glutathione; Extracellular; Intracellular; Biology; Oxidative stress; Antioxidant; Acetylcysteine; Transfection; Reactive oxygen species; Adenosine triphosphate; Cell culture; Molecular biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342422,0.0003443369,0.0002633573,0.0001957824,0.000184329,0.0002840485,0.0003113395,0.0004872778,0.001286058],"category_scores_gemma":[0.0001358576,0.0001868996,0.0003239923,0.0001248649,0.0003377652,0.0002510929,0.000205951,0.0005865856,0.0002715269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000259468,"about_ca_system_score_gemma":0.0002544088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009357014,"about_ca_topic_score_gemma":0.001555924,"domain_scores_codex":[0.9998635,0.00003094447,0.00001633771,0.00002079601,0.00002708242,0.00004137515],"domain_scores_gemma":[0.9998947,0.00001402566,0.00003055905,0.00002661882,0.00001155153,0.00002249171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008973695,0.00008499317,0.0002277811,0.0000312245,0.00002119929,0.000254757,0.00001596216,0.00005267405,0.9964685,0.0001831708,0.000106923,0.001655447],"study_design_scores_gemma":[0.00006703551,0.001226392,0.00732665,0.000006781169,0.00004973757,0.001312778,0.0001067207,0.000634187,0.9878075,0.0002363086,0.00121663,0.000009374306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972746,0.0006080376,0.0006935758,0.0001283582,0.0000432279,0.00001303748,0.0001411546,0.00008552719,0.001012508],"genre_scores_gemma":[0.9975597,0.0003985271,0.0006961979,0.00004934478,0.000007487242,0.00001233294,0.0001609555,0.00001356309,0.001101934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286058,"threshold_uncertainty_score":0.004302323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1146015833498299,"score_gpt":0.374782677265494,"score_spread":0.2601810939156641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}