{"id":"W2000067978","doi":"10.1242/dev.088948","title":"Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells","year":2013,"lang":"en","type":"article","venue":"Development","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"RANKL; Paracrine signalling; Biology; Internal medicine; Progenitor cell; Endocrinology; Progesterone receptor; Cellular differentiation; Cell biology; Receptor; Stem cell; Estrogen receptor; Medicine; Activator (genetics); Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475327,0.0001442483,0.0001724956,0.0002080106,0.0001820721,0.0003212987,0.00009770934,0.0001891115,0.001314907],"category_scores_gemma":[0.0001092665,0.0001132932,0.0001645742,0.0001367378,0.0001913125,0.0001363943,0.0002228413,0.0003979581,0.0004600228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003908721,"about_ca_system_score_gemma":0.0003194587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002013731,"about_ca_topic_score_gemma":0.003140557,"domain_scores_codex":[0.9998512,0.00001976186,0.00001234321,0.00001843031,0.00004309403,0.00005503953],"domain_scores_gemma":[0.9999232,0.00001379389,0.00001564156,0.000009094227,0.000009220858,0.00002908646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007429015,0.00001363608,0.0003019758,0.00003055387,0.000001294041,0.00007788222,0.0000387113,0.00002734079,0.9974408,0.0001668444,0.00003488467,0.001791705],"study_design_scores_gemma":[0.00001769687,0.000185842,0.01077972,0.000009075266,0.000007649359,0.0003419704,0.0001176171,0.0006119849,0.9825107,0.00007686886,0.005337265,0.000003645564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924747,0.002324393,0.001787488,0.0001547364,0.00001543445,0.00002659793,0.0003810957,0.00006021597,0.002775325],"genre_scores_gemma":[0.9944043,0.0005576357,0.001108478,0.00004067214,0.000005530795,0.00001625216,0.0002584942,0.000006926422,0.00360156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002013731,"threshold_uncertainty_score":0.004398823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090882267530367,"score_gpt":0.2188226881917198,"score_spread":0.2079138655164161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}