{"id":"W2000087607","doi":"10.1089/ars.2011.4391","title":"The Cystine/Glutamate Antiporter System x <sub>c</sub> <sup>−</sup> in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities","year":2012,"lang":"en","type":"review","venue":"Antioxidants and Redox Signaling","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":960,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institute of Neurological Disorders and Stroke; National Eye Institute; Fondation Charcot; National Institutes of Health; Alzheimer's Association","keywords":"Cystine; Antiporter; Cysteine; Glutamate receptor; Glutathione; Biochemistry; Amino acid; Biology; Extracellular; Cell biology; Neuroprotection; Internalization; Glutamic acid; Chemistry; Biophysics; Pharmacology; Cell; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006945611,0.0005751001,0.001082288,0.0001202075,0.0002953748,0.0001478146,0.0002572771,0.0002885075,0.000001912539],"category_scores_gemma":[0.00002664238,0.0003923469,0.0002164218,0.0001247506,0.0001093859,0.0000130062,0.0002518566,0.0002331007,0.000003950789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002243195,"about_ca_system_score_gemma":0.0003036933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004612454,"about_ca_topic_score_gemma":0.00000395339,"domain_scores_codex":[0.997344,0.0002415532,0.0008169551,0.0006859214,0.000241665,0.0006698996],"domain_scores_gemma":[0.9984317,0.00004931137,0.0003909438,0.0004843559,0.0000524695,0.0005911936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008868264,0.0001505467,0.00002500882,0.008538742,0.0006612327,0.00009567293,0.0003000356,0.00003927332,0.09058432,0.004412474,0.00008907918,0.8950149],"study_design_scores_gemma":[0.001191591,0.0002194559,0.0001047333,0.01526806,0.001124527,0.0002270768,0.001512496,0.0002505553,0.006176539,0.00018482,0.9720232,0.001716924],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03271649,0.9615308,0.004394254,0.00009235642,0.0002038641,0.0007573008,0.0002662692,0.00002290828,0.00001572311],"genre_scores_gemma":[0.0950982,0.9034595,0.0002744039,0.0003933994,0.0002856057,0.00007421109,0.0002490682,0.0000969109,0.00006873109],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9719341,"threshold_uncertainty_score":0.9998528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03428381886605469,"score_gpt":0.2716804283832402,"score_spread":0.2373966095171855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}