{"id":"W2000087607","doi":"10.1089/ars.2011.4391","title":"The Cystine/Glutamate Antiporter System x <sub>c</sub> <sup>−</sup> in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities","year":2012,"lang":"en","type":"review","venue":"Antioxidants and Redox Signaling","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":960,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institute of Neurological Disorders and Stroke; National Eye Institute; Fondation Charcot; National Institutes of Health; Alzheimer's Association","keywords":"Cystine; Antiporter; Cysteine; Glutamate receptor; Glutathione; Biochemistry; Amino acid; Biology; Extracellular; Cell biology; Neuroprotection; Internalization; Glutamic acid; Chemistry; Biophysics; Pharmacology; Cell; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396,0.0005589395,0.0008084544,0.0004288398,0.0001855437,0.0008820943,0.0003693705,0.0007934777,0.001064742],"category_scores_gemma":[0.0001064369,0.0001208343,0.0002460775,0.0003310807,0.0003922837,0.0008028467,0.0004183,0.001050035,0.0006139097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004868272,"about_ca_system_score_gemma":0.0004678185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003855263,"about_ca_topic_score_gemma":0.0005600698,"domain_scores_codex":[0.9999373,0.00001029182,0.00001095987,0.000009191909,0.00001595287,0.00001632072],"domain_scores_gemma":[0.999929,0.00001264627,0.00001745515,0.000002443881,0.0000206997,0.00001786823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001891451,0.0002290905,0.002154995,0.01405955,0.0002695233,0.001450233,0.0002971708,0.0008615701,0.2003521,0.0165262,0.02540462,0.7365035],"study_design_scores_gemma":[0.0001452979,0.002135484,0.0129496,0.002150658,0.0008352167,0.007802994,0.0006736599,0.002013732,0.09741384,0.02111436,0.8526462,0.0001190004],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006696814,0.9891632,0.001096028,0.001509881,0.0004093908,0.000008551284,0.00003968671,0.00003846601,0.001037941],"genre_scores_gemma":[0.03852977,0.9548274,0.001309075,0.0009372574,0.001129364,0.0000190685,0.0001430784,0.00001086359,0.003094117],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001064742,"threshold_uncertainty_score":0.003561914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03428381886605469,"score_gpt":0.2716804283832402,"score_spread":0.2373966095171855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}