{"id":"W2000088111","doi":"10.1021/jm200274d","title":"Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Stiftelsen för Strategisk Forskning; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust","keywords":"Kinase; RNA splicing; SR protein; Alternative splicing; Phosphorylation; Chemistry; Serine; Biochemistry; DYRK1A; Tyrosine kinase; RNA; Gene; Biology; Messenger RNA; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009455697,0.0003179107,0.0002187518,0.0001942832,0.0001215872,0.0001728517,0.0001601814,0.0001686725,0.000967952],"category_scores_gemma":[0.00008151948,0.00007740268,0.00017105,0.0001246751,0.0001406041,0.0002029631,0.0001502446,0.0004470222,0.0003225189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001505176,"about_ca_system_score_gemma":0.0001594062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002799813,"about_ca_topic_score_gemma":0.001006913,"domain_scores_codex":[0.9999681,0.000005652515,0.000003471385,0.000006761847,0.000008467461,0.000007565821],"domain_scores_gemma":[0.9999577,0.000006319534,0.00001226267,0.000003314312,0.000005634035,0.00001476753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005332741,0.0001938581,0.0005982617,0.0003149738,0.00002766896,0.0002959907,0.00005227612,0.0009434011,0.9651119,0.0004628871,0.0003274121,0.03113814],"study_design_scores_gemma":[0.000292015,0.004370537,0.004298371,0.00002811018,0.00006002086,0.001343816,0.00004754887,0.0009474895,0.9552529,0.0002065403,0.03312038,0.00003234481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463902,0.02995234,0.01116385,0.0003132291,0.00009948519,0.0004132645,0.001123182,0.0001714917,0.01037288],"genre_scores_gemma":[0.9680219,0.01516494,0.009550438,0.0002184673,0.00003871904,0.0001360892,0.001570376,0.00002089142,0.005277999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000967952,"threshold_uncertainty_score":0.003238142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02429651951916617,"score_gpt":0.246892979274455,"score_spread":0.2225964597552888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}