{"id":"W2000088111","doi":"10.1021/jm200274d","title":"Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Stiftelsen för Strategisk Forskning; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust","keywords":"Kinase; RNA splicing; SR protein; Alternative splicing; Phosphorylation; Chemistry; Serine; Biochemistry; DYRK1A; Tyrosine kinase; RNA; Gene; Biology; Messenger RNA; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008488309,0.0003551762,0.0008811524,0.00006007341,0.00005168418,0.000009574338,0.0003896274,0.0002489201,0.0007560553],"category_scores_gemma":[0.001128023,0.0002736631,0.0002021202,0.0002365967,0.0005385808,0.000127695,0.000218369,0.000498789,1.742314e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001519284,"about_ca_system_score_gemma":0.0001559053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005753633,"about_ca_topic_score_gemma":0.00000723416,"domain_scores_codex":[0.9967105,0.00007606708,0.00168212,0.0003193862,0.0009726812,0.0002391799],"domain_scores_gemma":[0.995163,0.0006877219,0.002831069,0.0004940192,0.0006654314,0.0001587766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001348425,0.0003036562,0.01074629,0.000512881,0.0002853452,0.00004641021,0.001096548,0.00005049274,0.9785421,0.000004125824,0.00007381661,0.006989843],"study_design_scores_gemma":[0.001968934,0.0001195442,0.04446591,0.001439831,0.000409323,0.0002918274,0.001233297,0.0006404914,0.9489312,0.000273259,0.00002921491,0.0001972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972117,0.0008472245,0.0002918851,0.000173306,0.0001623025,0.000091257,0.00006329922,0.0000133731,0.001145671],"genre_scores_gemma":[0.9965169,0.0002472108,0.002300201,0.00001194157,0.0007159463,0.000001967709,0.00003794484,0.0000411836,0.0001267272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03371962,"threshold_uncertainty_score":0.9999716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02429651951916617,"score_gpt":0.246892979274455,"score_spread":0.2225964597552888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}