{"id":"W2000118489","doi":"10.1038/nm.3230","title":"A largely random AAV integration profile after LPLD gene therapy","year":2013,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"FP7 Health; Universiteit van Amsterdam","keywords":"Vector (molecular biology); Genetic enhancement; Genome; Viral vector; Biology; Gene; Virology; Computational biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005892015,0.0003582339,0.0004716743,0.0004316545,0.0002716157,0.001198302,0.0002232145,0.000474857,0.001482989],"category_scores_gemma":[0.001184807,0.0003389327,0.0002249286,0.0002965876,0.0005245986,0.0004611465,0.0003763027,0.001005633,0.001133319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005150005,"about_ca_system_score_gemma":0.0004778315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006042479,"about_ca_topic_score_gemma":0.0009225392,"domain_scores_codex":[0.9990804,0.0001548455,0.00009001507,0.0002453783,0.000255425,0.0001738384],"domain_scores_gemma":[0.9991974,0.0002933017,0.0001411982,0.0001446632,0.0001355724,0.00008793665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001119239,0.00003191268,0.0005166498,0.00002675342,0.000007286652,0.00003462223,0.00003072822,0.0003321194,0.9942484,0.0002758655,0.00005301635,0.004330797],"study_design_scores_gemma":[0.000007772926,0.0002039366,0.00247314,0.000005079532,0.00001732999,0.0001535949,0.00002053339,0.001714721,0.9942223,0.0001485798,0.001024173,0.000008832912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9140849,0.0009582367,0.07790495,0.000160507,0.00007058206,0.0001801051,0.0007050466,0.0008803717,0.005055318],"genre_scores_gemma":[0.9809617,0.0003051943,0.01432635,0.00009514408,0.00001190516,0.00007846599,0.0005758288,0.0003484791,0.003296904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482989,"threshold_uncertainty_score":0.004961133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008343047399598057,"score_gpt":0.2950104059377488,"score_spread":0.2866673585381507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}