{"id":"W2000120982","doi":"10.1016/j.radonc.2009.08.017","title":"Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3","year":2009,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Cancer Research UK","keywords":"ATF4; Unfolded protein response; Hypoxia (environmental); Cancer research; ATF3; Small hairpin RNA; Biology; Metastasis; Gene expression; Proteasome; Endoplasmic reticulum; Cell biology; Gene knockdown; Chemistry; Gene; Cancer; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281135,0.00009653121,0.0001713118,0.00002179988,0.00007820791,0.000004742588,0.000170051,0.000157725,0.00001076594],"category_scores_gemma":[0.0001725238,0.00005500541,0.00009331857,0.00009815121,0.0001325329,0.00000427762,0.00003206958,0.00006984417,4.946143e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003104016,"about_ca_system_score_gemma":0.0001348631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001016161,"about_ca_topic_score_gemma":0.000005179443,"domain_scores_codex":[0.9989667,0.0004720222,0.0001913509,0.0001540521,0.0001015011,0.0001144025],"domain_scores_gemma":[0.9993685,0.00004361015,0.0002453081,0.0002607257,0.00004959749,0.000032263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001077372,0.0001629292,0.0006580619,0.000006291729,0.00003371332,3.800741e-7,0.0001206419,0.00002631753,0.9927311,0.00005965041,0.0001486038,0.004974933],"study_design_scores_gemma":[0.001125732,0.0005423498,0.03307445,0.00003274701,0.00001755904,0.00000338457,0.00004194856,0.00001497846,0.9633209,0.0002246396,0.001538761,0.00006261269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978306,0.0008597082,0.00008223277,0.0007525405,0.00005040805,0.0002983909,0.00001704815,0.000003478261,0.0001056466],"genre_scores_gemma":[0.9990897,0.0001884216,0.000216243,0.0003282908,0.00003019036,0.00001373678,0.000005981385,0.000006561339,0.0001209067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03241639,"threshold_uncertainty_score":0.2243055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053223740175054,"score_gpt":0.2665703953747274,"score_spread":0.2560381579729769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}