{"id":"W2000121640","doi":"10.3727/096504010x12704916124828","title":"The Inhibitor of Growth 1 (ING1) Is Involved in Trichostatin A-Induced Apoptosis and Caspase 3 Signaling in p53-Deficient Glioblastoma Cells","year":2009,"lang":"en","type":"article","venue":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Trichostatin A; Cancer research; Apoptosis; Biology; Gene knockdown; Glioma; Histone; Histone deacetylase; Histone deacetylase inhibitor; Death domain; DNA damage; Molecular biology; Programmed cell death; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005042395,0.0003399414,0.0001984705,0.0002088016,0.000141079,0.0001919506,0.0001164753,0.000141157,0.001253628],"category_scores_gemma":[0.00005057787,0.00009117618,0.0002065924,0.0001879309,0.0001287344,0.00009611176,0.0001183345,0.0003776401,0.0004023479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244322,"about_ca_system_score_gemma":0.0001882271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006366118,"about_ca_topic_score_gemma":0.001112888,"domain_scores_codex":[0.9999323,0.000007048654,0.000005089375,0.00001199829,0.00002226712,0.00002120856],"domain_scores_gemma":[0.9999628,0.000003836594,0.00001460294,0.000003447929,0.00000451394,0.00001069405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001647849,0.0000259859,0.0007774746,0.00006077222,0.000008776628,0.0000880119,0.000009624919,0.00004070384,0.9961176,0.0000598039,0.0001397634,0.002506663],"study_design_scores_gemma":[0.00002979992,0.0005444986,0.02683936,0.00001071277,0.00005603633,0.0009972731,0.00005414802,0.0008151178,0.9599519,0.0000743815,0.01062258,0.000004233547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884852,0.00564835,0.002220862,0.0002206095,0.00004868123,0.00003932507,0.001075954,0.0001665362,0.002094411],"genre_scores_gemma":[0.9887508,0.003492623,0.001544873,0.0000957378,0.000009764762,0.00003961051,0.002169095,0.0000167983,0.003880794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253628,"threshold_uncertainty_score":0.004193842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1066155865699579,"score_gpt":0.4595628890268401,"score_spread":0.3529473024568821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}