{"id":"W2000123112","doi":"10.1023/b:drug.0000026258.02846.1c","title":"Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma","year":2004,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Regional Cancer Foundation; Hamilton Regional Laboratory Medicine Program; McGill University","funders":"National Cancer Institute; McGill University","keywords":"Nausea; Medicine; Gastroenterology; Internal medicine; Vomiting; Diarrhea; Melanoma; Progressive disease; Anorexia; Toxicity; Regimen; Phases of clinical research; Surgery; Chemotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002394354,0.0002001224,0.0002498833,0.0001194402,0.00005688105,0.00001277003,0.0001697,0.0001146502,0.00002930346],"category_scores_gemma":[0.0001871921,0.0001898436,0.0001019104,0.0001717239,0.0001173472,0.00001035861,0.00008966221,0.00009439985,0.00001529574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003920853,"about_ca_system_score_gemma":0.0009667674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004674412,"about_ca_topic_score_gemma":0.0001882738,"domain_scores_codex":[0.9984835,0.00008338274,0.000533783,0.0003672424,0.0002961625,0.0002358885],"domain_scores_gemma":[0.9992597,0.00002370369,0.0001795137,0.0002621604,0.00007018764,0.0002047053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003463191,0.001360273,0.0001321979,0.00003060083,0.00007115663,0.00005286096,0.0004002691,0.0006293195,0.9872986,0.003960993,0.000653961,0.001946594],"study_design_scores_gemma":[0.0747743,0.002993667,0.000103742,0.00007408797,0.00003683345,0.00002153135,0.00006191953,0.00003251214,0.9106226,0.008556578,0.002479939,0.0002422692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976671,0.0002287831,0.0002571511,0.0005646243,0.0002302335,0.0004554853,0.00008918453,0.00001214749,0.000495323],"genre_scores_gemma":[0.995729,0.00002094194,0.002568599,0.0003034574,0.0003225739,0.00004253558,0.000538587,0.00002050182,0.0004538001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07667597,"threshold_uncertainty_score":0.7741597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107754542709329,"score_gpt":0.2726131858557945,"score_spread":0.2515356404287012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}