{"id":"W2000123112","doi":"10.1023/b:drug.0000026258.02846.1c","title":"Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma","year":2004,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Regional Cancer Foundation; Hamilton Regional Laboratory Medicine Program; McGill University","funders":"National Cancer Institute; McGill University","keywords":"Nausea; Medicine; Gastroenterology; Internal medicine; Vomiting; Diarrhea; Melanoma; Progressive disease; Anorexia; Toxicity; Regimen; Phases of clinical research; Surgery; Chemotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009792295,0.001290132,0.001831726,0.0004425451,0.0004952002,0.0007672113,0.0008108979,0.00112825,0.002803592],"category_scores_gemma":[0.0007221702,0.0004698168,0.0009505878,0.0003532533,0.0009513634,0.0007432466,0.0002366713,0.002763746,0.0005181325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008702683,"about_ca_system_score_gemma":0.0009450795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002040631,"about_ca_topic_score_gemma":0.004979413,"domain_scores_codex":[0.9997649,0.00009641721,0.000007196417,0.00003215358,0.00001945145,0.00007996461],"domain_scores_gemma":[0.9995629,0.00008820092,0.00005260638,0.0000349211,0.0000204865,0.0002409101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7272049,0.05093186,0.004622452,0.001011858,0.001173615,0.0005914388,0.0004397559,0.004543983,0.07544234,0.0009130421,0.00648013,0.1266446],"study_design_scores_gemma":[0.4745232,0.4989129,0.01168799,0.00006081513,0.0004068326,0.0004321541,0.0001515262,0.002007929,0.007267707,0.0004853298,0.004023065,0.00004045975],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913124,0.003414681,0.0004739635,0.0006838046,0.0002307571,0.000910648,0.0006205802,0.00007181702,0.002281263],"genre_scores_gemma":[0.9884322,0.003143045,0.0008225768,0.0005568094,0.0002018464,0.001059503,0.001235714,0.0000271165,0.004521092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002803592,"threshold_uncertainty_score":0.00937897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107754542709329,"score_gpt":0.2726131858557945,"score_spread":0.2515356404287012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}