{"id":"W2000135530","doi":"10.1159/000371445","title":"Three Novel Pathogenic Mutations in K<sub>ATP</sub> Channel Genes and Somatic Imprinting Alterations of the 11p15 Region in Pancreatic Tissue in Patients with Congenital Hyperinsulinism","year":2015,"lang":"en","type":"article","venue":"Hormone Research in Paediatrics","topic":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"Division of Materials Research; National Research Foundation","keywords":"Multiplex ligation-dependent probe amplification; Loss of heterozygosity; Congenital hyperinsulinism; Biology; Atypical adenomatous hyperplasia; Molecular biology; Genetics; Gene; Endocrinology; Exon; Allele; Insulin; Cancer; Hyperinsulinism; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001027382,0.0002281095,0.0005237528,0.0008588847,0.00009001638,0.0000384747,0.0001982349,0.0002027176,0.000001387235],"category_scores_gemma":[0.001344001,0.000176583,0.0000529879,0.001701541,0.0002501672,0.0001905568,0.0001957285,0.0006300764,0.00000379824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184992,"about_ca_system_score_gemma":0.0004451416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002888125,"about_ca_topic_score_gemma":0.001050386,"domain_scores_codex":[0.9969699,0.0001848521,0.0008481843,0.0004223367,0.0009176977,0.0006569993],"domain_scores_gemma":[0.9982042,0.0005485793,0.0001187559,0.0003923497,0.0004988881,0.000237191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009474267,0.001692482,0.9762397,0.000211121,0.00003559066,0.0001439367,0.00417292,0.0002292298,0.01066762,0.0003106001,0.00003035842,0.005319049],"study_design_scores_gemma":[0.01980375,0.001622843,0.9625804,0.0002844466,0.00007998468,0.00002722104,0.0008881962,0.01278436,0.0003846747,0.001192815,0.00003855677,0.0003127966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947253,0.002651781,0.0001941934,0.0004531113,0.00008472706,0.00167721,0.00003879315,0.00001276947,0.0001620411],"genre_scores_gemma":[0.9984208,0.0006762015,0.0004668752,0.0000287219,0.00007194132,0.0002418139,0.00004979606,0.00003394565,0.000009840369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01885632,"threshold_uncertainty_score":0.7200847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04544362295861201,"score_gpt":0.2986042964697535,"score_spread":0.2531606735111415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}