{"id":"W2000168712","doi":"10.1042/bj20020375","title":"Embryonic extracts derived from the nematode Caenorhabditis elegans remove uracil from DNA by the sequential action of uracil-DNA glycosylase and AP (apurinic/apyrimidinic) endonuclease","year":2002,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"AP site; Uracil; DNA glycosylase; Thymine; Biochemistry; DNA; Uracil-DNA glycosylase; Guanine; Base excision repair; Biology; Endonuclease; Cytosine; Deamination; DNA damage; Chemistry; Nucleotide; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009128536,0.0008261313,0.0003421303,0.0002317792,0.0001539246,0.0002101296,0.0002281481,0.0002990179,0.0006777902],"category_scores_gemma":[0.0001113122,0.0002840409,0.0002232931,0.0001147031,0.0001738373,0.0001331455,0.0002368169,0.0005006646,0.0003584109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002231975,"about_ca_system_score_gemma":0.0003420558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007918777,"about_ca_topic_score_gemma":0.002568694,"domain_scores_codex":[0.9998864,0.000008642007,0.00001482147,0.00003206428,0.00004040688,0.00001769778],"domain_scores_gemma":[0.9998827,0.00002384006,0.00004102699,0.00001269676,0.00001658056,0.00002313057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000135922,0.000006144144,0.000115452,0.00002603313,0.00000256467,0.00003951641,0.000006525728,0.00001145689,0.9991767,0.00001859152,0.00001093746,0.0005723903],"study_design_scores_gemma":[0.000006115338,0.0001365041,0.006211224,0.000008986221,0.00001602029,0.0002235783,0.00001263266,0.0001759896,0.9903195,0.00001811747,0.002865508,0.000005862684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832479,0.002638286,0.01064516,0.00005480944,0.00006938678,0.0001952077,0.0009429033,0.0001459277,0.002060397],"genre_scores_gemma":[0.9481284,0.003519888,0.03063677,0.000110917,0.0000363699,0.0002317443,0.006499211,0.00008065745,0.01075597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008261313,"threshold_uncertainty_score":0.00226742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075977302423084,"score_gpt":0.2383180433987906,"score_spread":0.2175582703745597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}