{"id":"W2000176602","doi":"10.1016/j.antiviral.2005.07.003","title":"Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir","year":2005,"lang":"en","type":"article","venue":"Antiviral Research","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Protease; Biology; Virology; HIV-1 protease; Protease inhibitor (pharmacology); Saquinavir; Mutation; Genetics; Virus; Enzyme; Gene; Biochemistry; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554335,0.0003740787,0.0003598632,0.0003590052,0.0002945468,0.0006178714,0.0004402314,0.000340908,0.001825318],"category_scores_gemma":[0.000442381,0.0002045563,0.0004158914,0.0003877376,0.000232636,0.0001645017,0.0003175715,0.0008518943,0.0007501292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230183,"about_ca_system_score_gemma":0.0001862938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001598301,"about_ca_topic_score_gemma":0.00130573,"domain_scores_codex":[0.9997074,0.00005449239,0.00002149826,0.0000479986,0.00006589506,0.0001027296],"domain_scores_gemma":[0.9997867,0.00007664503,0.00003031438,0.00003293049,0.00002649754,0.00004702527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001242787,0.00007099047,0.0006552685,0.000008072012,0.000006793945,0.000129679,0.00003309764,0.00008346156,0.9975238,0.00006119761,0.00005209166,0.001251247],"study_design_scores_gemma":[0.00009624525,0.002168473,0.07562602,0.00001910271,0.00009934672,0.005524126,0.0004172267,0.00349309,0.9073868,0.0002208352,0.004897923,0.00005076791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975209,0.0002019815,0.0006633666,0.00007045171,0.00001512655,0.00003852943,0.0005760521,0.00001823062,0.0008954675],"genre_scores_gemma":[0.9934993,0.0002847233,0.001395419,0.00008533386,0.00001299823,0.00003397553,0.002180875,0.00005230671,0.002455156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825318,"threshold_uncertainty_score":0.006106317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610441450119085,"score_gpt":0.3331935398410232,"score_spread":0.2970891253398323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}