{"id":"W2000184987","doi":"10.1523/jneurosci.1165-14.2014","title":"Synaptic and Cognitive Improvements by Inhibition of 2-AG Metabolism Are through Upregulation of MicroRNA-188-3p in a Mouse Model of Alzheimer's Disease","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; University of British Columbia; China Scholarship Council; National Institute on Aging; National Institutes of Health; Louisiana State University","keywords":"Monoacylglycerol lipase; Endocannabinoid system; Neuroinflammation; Long-term potentiation; Downregulation and upregulation; Amyloid precursor protein; Hippocampus; Chemistry; Hippocampal formation; Gene knockdown; Cell biology; Amyloid beta; Neuroscience; Amyloid precursor protein secretase; Peroxisome proliferator-activated receptor; Synaptic plasticity; Biology; Alzheimer's disease; Receptor; Biochemistry; Internal medicine; Medicine; Inflammation; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002588627,0.001062776,0.0009096231,0.0007284891,0.0002744573,0.0004609039,0.0003905281,0.0007046547,0.001328423],"category_scores_gemma":[0.0001353903,0.0004088884,0.0006785713,0.0003017207,0.0005657341,0.0003835957,0.0002403159,0.001671493,0.0006341101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003606765,"about_ca_system_score_gemma":0.0003619148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005512867,"about_ca_topic_score_gemma":0.0007936898,"domain_scores_codex":[0.9996793,0.00003704486,0.00004439486,0.00008521938,0.00008949689,0.00006445801],"domain_scores_gemma":[0.9998471,0.00001076544,0.00005650067,0.00001566315,0.0000192249,0.00005077096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005153182,0.0001358471,0.0000995288,0.0000521859,0.00001389219,0.00007431195,0.00002303208,0.0000408859,0.9978942,0.00009202609,0.00007809356,0.0009806539],"study_design_scores_gemma":[0.0001748405,0.002075048,0.004472276,0.00001782903,0.000100506,0.0004311414,0.00006274622,0.001214395,0.9875343,0.0001797781,0.003718472,0.00001875246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873183,0.002461145,0.005668764,0.0004424937,0.0002313195,0.0001337602,0.001289713,0.0006490592,0.001805501],"genre_scores_gemma":[0.9832658,0.002629132,0.006302617,0.0002888967,0.00005003376,0.0004048043,0.001222325,0.0001349163,0.005701531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328423,"threshold_uncertainty_score":0.004443944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02727242336049275,"score_gpt":0.2992359966121051,"score_spread":0.2719635732516124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}