{"id":"W2000194482","doi":"10.1634/stemcells.2006-0699","title":"Ex Vivo Gene Therapy for Hemophilia A That Enhances Safe Delivery and Sustained In Vivo Factor VIII Expression from Lentivirally Engineered Endothelial Progenitors","year":2007,"lang":"en","type":"article","venue":"Stem Cells","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Queen's University","funders":"National Heart, Lung, and Blood Institute","keywords":"Progenitor cell; Genetic enhancement; Ex vivo; In vivo; Transgene; Immunology; Biology; Gene delivery; Stem cell; Cancer research; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951921,0.000284439,0.0001879943,0.0002311128,0.0000936094,0.0003346651,0.0001633821,0.0002677415,0.001113319],"category_scores_gemma":[0.00008152919,0.0001487288,0.0001866481,0.0001224531,0.0002374749,0.000224696,0.0001157966,0.0006723499,0.0002522464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001951547,"about_ca_system_score_gemma":0.0001792699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002429093,"about_ca_topic_score_gemma":0.0002657778,"domain_scores_codex":[0.9999002,0.00002486497,0.000007989719,0.00001735779,0.00003166134,0.0000178433],"domain_scores_gemma":[0.999949,0.000009896246,0.00001692082,0.000007913606,0.000003815561,0.00001247291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001038772,0.00008269857,0.00006196702,0.0000253154,0.000003572249,0.00004070944,0.00001164056,0.000108051,0.9968221,0.0002399425,0.00004842118,0.002451649],"study_design_scores_gemma":[0.00007599482,0.001151987,0.001375025,0.00000649491,0.00002177043,0.0005199654,0.000008891623,0.001201962,0.9913995,0.00009563325,0.004138018,0.000004814627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822497,0.001884745,0.01382156,0.0001431533,0.0000387002,0.00007072814,0.000212894,0.0001438346,0.001434654],"genre_scores_gemma":[0.9867678,0.001785337,0.008196859,0.00004634083,0.00002538024,0.0000631765,0.0002789281,0.00003133273,0.002804857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113319,"threshold_uncertainty_score":0.003724456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505760341523173,"score_gpt":0.2611316507806782,"score_spread":0.2460740473654464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}