{"id":"W2000194482","doi":"10.1634/stemcells.2006-0699","title":"Ex Vivo Gene Therapy for Hemophilia A That Enhances Safe Delivery and Sustained In Vivo Factor VIII Expression from Lentivirally Engineered Endothelial Progenitors","year":2007,"lang":"en","type":"article","venue":"Stem Cells","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Queen's University","funders":"National Heart, Lung, and Blood Institute","keywords":"Progenitor cell; Genetic enhancement; Ex vivo; In vivo; Transgene; Immunology; Biology; Gene delivery; Stem cell; Cancer research; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003263637,0.0002777163,0.0002562075,0.0001099473,0.00007721848,0.00004316069,0.0002537979,0.0002275065,0.00007264866],"category_scores_gemma":[0.00000780227,0.0002473402,0.000115834,0.00008460019,0.0000705271,0.00001293436,0.0000828948,0.0001017502,0.000003400724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000405632,"about_ca_system_score_gemma":0.0001029043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003408854,"about_ca_topic_score_gemma":0.0001505354,"domain_scores_codex":[0.9982946,0.00009102566,0.0002827481,0.0005567381,0.0002457507,0.0005291561],"domain_scores_gemma":[0.9992791,0.00008269826,0.00008977309,0.0003364889,0.00008617493,0.0001257861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005785502,0.00009404621,0.0005232695,0.00002599326,0.00006013428,0.000009714415,0.0002416603,0.000009712086,0.985791,7.44961e-7,0.0001509886,0.007307282],"study_design_scores_gemma":[0.002575224,0.00123555,0.0001545318,0.00002145313,0.000005187504,0.000001049077,0.0002679943,0.00003050484,0.9909381,0.00002119521,0.004473103,0.0002761544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942035,0.002916481,0.001095764,0.00002526253,0.0002138275,0.001112747,0.0003526579,0.0000186056,0.0000611548],"genre_scores_gemma":[0.9964607,0.00127298,0.0006030141,0.00006804839,0.0003212283,0.00006792982,0.00004158291,0.00005463231,0.001109827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007031127,"threshold_uncertainty_score":0.9999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505760341523173,"score_gpt":0.2611316507806782,"score_spread":0.2460740473654464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}