{"id":"W2000241544","doi":"10.1096/fj.08-112680","title":"Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Cancer Care Ontario; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Wellcome Trust","keywords":"Aggrecan; Aggrecanase; ADAMTS; Chemistry; Cartilage; Thrombospondin; Disintegrin; Cartilage oligomeric matrix protein; Proteoglycan; Biochemistry; Cell biology; Osteoarthritis; Matrix metalloproteinase; Pharmacology; Metalloproteinase; Extracellular matrix; Biology; Medicine; Anatomy; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008975025,0.0004828235,0.0002343534,0.0001625212,0.0001047511,0.0001431452,0.0001377536,0.0001663887,0.0007694337],"category_scores_gemma":[0.00007673033,0.0001178657,0.000219598,0.0001426085,0.0001615661,0.0001052448,0.0001384104,0.0003340597,0.0001799798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159367,"about_ca_system_score_gemma":0.0002234837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006348024,"about_ca_topic_score_gemma":0.0008418939,"domain_scores_codex":[0.9998879,0.00001638364,0.000009560263,0.00002469167,0.0000430263,0.00001841561],"domain_scores_gemma":[0.9999408,0.000009452103,0.00002097503,0.000005386222,0.000007510504,0.00001586887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115805,0.00002204281,0.00009340349,0.00006562337,0.00000841281,0.00003918666,0.000003753464,0.0001235761,0.9967275,0.00006507712,0.00005066007,0.002684961],"study_design_scores_gemma":[0.00002203226,0.0004342815,0.001428153,0.000004681389,0.00001589768,0.0003188587,0.000003882104,0.0004476205,0.9924771,0.00002810999,0.004815241,0.000004189856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566271,0.02481998,0.01383217,0.0002683495,0.0001239477,0.0001205016,0.0004558581,0.0002151664,0.003536896],"genre_scores_gemma":[0.9781402,0.008600772,0.007515347,0.00009131015,0.00003494184,0.00006625184,0.0004943779,0.00002641407,0.005030261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007694337,"threshold_uncertainty_score":0.002574027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414576058929963,"score_gpt":0.2487424392561211,"score_spread":0.2245966786668214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}