{"id":"W2000279978","doi":"10.1021/jm100432w","title":"Improved Syntheses of 5′-<i>S</i>-(2-Aminoethyl)-6-<i>N</i>-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), Analogues, and Fluorescent Probe Conjugates: Analysis of Cell-Surface Human Equilibrative Nucleoside Transporter 1 (hENT1) Levels for Prediction of the Antitumor Efficacy of Gemcitabine","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Nucleoside; Fluorescence; Conjugate; Nucleoside transporter; Stereochemistry; Fluorescein isothiocyanate; Transporter; Fluorescein; Isothiocyanate; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003364339,0.0005029305,0.0004689834,0.0002118874,0.0001632322,0.0002194868,0.000477382,0.0003633772,0.0009372838],"category_scores_gemma":[0.0003403287,0.000294269,0.0003376852,0.0002484636,0.000152267,0.0003144506,0.0001976177,0.0006145868,0.0005772381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004165451,"about_ca_system_score_gemma":0.0004644662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007064662,"about_ca_topic_score_gemma":0.0016038,"domain_scores_codex":[0.9998022,0.00003924357,0.00002433619,0.00004678248,0.00005162146,0.00003593782],"domain_scores_gemma":[0.9998271,0.00002803719,0.00005374325,0.00002581742,0.00004001713,0.00002528604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004667891,0.00002866713,0.00005810957,0.00007256268,0.000007988341,0.0000571032,0.00003922326,0.0005957073,0.9961808,0.0002265091,0.00003997574,0.002646818],"study_design_scores_gemma":[0.00001336112,0.0002076819,0.0003642966,0.000003306604,0.00001276805,0.0001124654,0.00001022251,0.0007897259,0.996204,0.00003030575,0.002243133,0.000008747697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8988857,0.003512431,0.08889027,0.0001555558,0.00008617269,0.0004768346,0.00119504,0.0004524497,0.006345519],"genre_scores_gemma":[0.925689,0.003268113,0.06390883,0.00007997375,0.00002873917,0.0003597315,0.001584724,0.0001254228,0.004955437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009372838,"threshold_uncertainty_score":0.003135502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696478617686045,"score_gpt":0.2591373873489204,"score_spread":0.24217260117206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}