{"id":"W2000312682","doi":"10.1074/jbc.275.7.5043","title":"Distinct Central Amphipathic α-Helices in Apolipoprotein A-I Contribute to the in Vivo Maturation of High Density Lipoprotein by Either Activating Lecithin-Cholesterol Acyltransferase or Binding Lipids","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; University of Ottawa; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Apolipoprotein B; Cholesteryl ester; Cholesterol; Phospholipid; Biochemistry; Mutant; Lecithin; Lipoprotein; Recombinant DNA; Chemistry; Sterol O-acyltransferase; High-density lipoprotein; In vivo; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741251,0.0003270432,0.0001341272,0.00009858329,0.00009639161,0.0003232004,0.0002385852,0.0002080737,0.0003754001],"category_scores_gemma":[0.0001779698,0.0002225676,0.0002583404,0.00008843008,0.0002455335,0.0001869809,0.0001954934,0.0004507884,0.0003325196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002582033,"about_ca_system_score_gemma":0.0001536814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002503791,"about_ca_topic_score_gemma":0.0002802137,"domain_scores_codex":[0.9998995,0.00001928201,0.00001569498,0.00002070565,0.00002710919,0.00001765995],"domain_scores_gemma":[0.99981,0.00002323048,0.00007904653,0.00002278321,0.0000144865,0.00005037299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007534146,0.00001048547,0.000288864,0.000007487283,0.00000261173,0.00001915548,0.000005605626,0.00004440109,0.9990628,0.00005626414,0.000003825517,0.0004230586],"study_design_scores_gemma":[0.00002931014,0.0002115866,0.007500355,0.000005986734,0.00002659154,0.0004534525,0.00002863696,0.001602743,0.9890081,0.00008730761,0.001038589,0.000007229263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972062,0.0002839323,0.002107908,0.00001570135,0.000007803639,0.00001646266,0.0000395374,0.00001508506,0.0003073369],"genre_scores_gemma":[0.9956568,0.0002712734,0.003286742,0.00002146533,0.000005803757,0.00001746653,0.0002062358,0.00001008975,0.0005240196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003754001,"threshold_uncertainty_score":0.001873434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128140029410168,"score_gpt":0.2411324672844957,"score_spread":0.2298510669903941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}