{"id":"W2000312682","doi":"10.1074/jbc.275.7.5043","title":"Distinct Central Amphipathic α-Helices in Apolipoprotein A-I Contribute to the in Vivo Maturation of High Density Lipoprotein by Either Activating Lecithin-Cholesterol Acyltransferase or Binding Lipids","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; University of Ottawa; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Apolipoprotein B; Cholesteryl ester; Cholesterol; Phospholipid; Biochemistry; Mutant; Lecithin; Lipoprotein; Recombinant DNA; Chemistry; Sterol O-acyltransferase; High-density lipoprotein; In vivo; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006363883,0.0002548838,0.000425855,0.00004331538,0.00006514693,0.00003895774,0.0003959527,0.0004258429,0.0002208947],"category_scores_gemma":[0.0005543372,0.000154354,0.0001190773,0.0002719473,0.0001055656,0.00002145238,0.0000555088,0.0005693552,0.000001617596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009760947,"about_ca_system_score_gemma":0.00009469609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001748066,"about_ca_topic_score_gemma":0.00008444333,"domain_scores_codex":[0.9980813,0.0002118921,0.0007542979,0.0003101771,0.0002367664,0.0004055596],"domain_scores_gemma":[0.9991611,0.00006695191,0.0003135513,0.0002101975,0.00009728615,0.0001509389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002159752,0.000176221,0.006662601,0.00003397017,0.00003708828,0.000009292703,0.00009512865,0.00008893636,0.9853608,3.427251e-7,0.00008018972,0.005295673],"study_design_scores_gemma":[0.00112675,0.0003532718,0.008045471,0.0001713845,0.000006938445,0.00005577238,0.0001019319,0.00001396041,0.988741,0.00001230804,0.0011765,0.0001946667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986569,0.0001650238,0.0001784867,0.0005329092,0.00007540343,0.000286435,0.00007327961,0.000006252546,0.00002531428],"genre_scores_gemma":[0.9989553,0.0001459956,0.0001889965,0.0001773537,0.0003672254,0.00002069332,0.00002804404,0.00001626089,0.0001001185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005101006,"threshold_uncertainty_score":0.6294374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128140029410168,"score_gpt":0.2411324672844957,"score_spread":0.2298510669903941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}