{"id":"W2000314258","doi":"10.1073/pnas.112222199","title":"A genetically clamped renin transgene for the induction of hypertension","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Kidney Foundation of Canada","keywords":"Transgene; Renin–angiotensin system; Losartan; Biology; Kidney; Endocrinology; Internal medicine; Genetically modified mouse; Angiotensin II; Blood pressure; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005501555,0.0004723688,0.0004023567,0.0005409226,0.0003694663,0.0004127855,0.0008610155,0.0007427414,0.003388389],"category_scores_gemma":[0.0003961799,0.0004614576,0.0006057806,0.0002980749,0.0005518676,0.000471528,0.000581316,0.002097498,0.001190184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649512,"about_ca_system_score_gemma":0.0007172474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004624978,"about_ca_topic_score_gemma":0.0007629523,"domain_scores_codex":[0.9994734,0.000095797,0.00005836195,0.0001174454,0.0002024965,0.00005246225],"domain_scores_gemma":[0.9996477,0.0000717537,0.00007948055,0.00007706429,0.0000423449,0.0000816122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004097621,0.00004078491,0.00004654248,0.00003061525,0.00000565135,0.00006471379,0.00001797411,0.00003747191,0.9964589,0.0006573888,0.0001020686,0.002496832],"study_design_scores_gemma":[0.00007028211,0.0005841466,0.001058381,0.00002072546,0.00006077608,0.001199893,0.00001602229,0.0008498323,0.9744427,0.000240594,0.02143542,0.00002117753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4696747,0.004501726,0.4990431,0.001620095,0.001642241,0.002188925,0.002740054,0.00385582,0.0147334],"genre_scores_gemma":[0.6210892,0.005228548,0.3332343,0.0006668307,0.0001969391,0.001408837,0.005100803,0.001077951,0.03199651],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003388389,"threshold_uncertainty_score":0.01133525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1526687741109018,"score_gpt":0.3208947957396645,"score_spread":0.1682260216287627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}