{"id":"W2000340800","doi":"10.1136/heartjnl-2013-304613.173","title":"GW24-e2975 Over-expression of calpastatin aggravates <i>in vitro</i> and <i>in vivo</i> cardiotoxicity induced by doxorubicin","year":2013,"lang":"en","type":"article","venue":"Heart","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Calpain; Calpastatin; Doxorubicin; Cardiotoxicity; Apoptosis; Medicine; Pharmacology; Programmed cell death; Molecular biology; Cancer research; Cell biology; Internal medicine; Biology; Biochemistry; Chemotherapy; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490622,0.0001081716,0.0001682939,0.000050847,0.00002514953,0.00001099561,0.00003750852,0.0001461747,0.00004143064],"category_scores_gemma":[0.00003713317,0.00009755325,0.00004304253,0.00009113231,0.00003789262,0.000007240296,0.00004477429,0.00008287952,0.000002982572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001133178,"about_ca_system_score_gemma":0.00002123002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005302725,"about_ca_topic_score_gemma":0.00003503594,"domain_scores_codex":[0.9991829,0.00008994527,0.0002177618,0.0002406352,0.000106535,0.0001622717],"domain_scores_gemma":[0.9996768,0.00001588892,0.00005348631,0.0001594413,0.00003215637,0.00006221695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009492429,0.0000495862,0.004525802,0.00002116906,0.000003092938,3.292575e-7,0.0000233955,0.00001012645,0.9852096,0.00000161885,0.009755242,0.0003050441],"study_design_scores_gemma":[0.0006677154,0.00007089282,0.01293306,0.00003241022,0.000002098096,0.000002780648,0.00003727702,0.0001342456,0.9780872,0.00002563157,0.007900119,0.0001065623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987718,0.0002890332,0.00007731868,0.0002059019,0.00005339639,0.0003532392,0.00001792904,0.000006360385,0.0002249606],"genre_scores_gemma":[0.9990741,0.00003737334,0.0002055622,0.0002680726,0.00004549913,0.0000425009,0.00003729571,0.00001139906,0.00027819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008407255,"threshold_uncertainty_score":0.3978106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00474396977793912,"score_gpt":0.219449771588388,"score_spread":0.2147058018104489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}