{"id":"W2000340800","doi":"10.1136/heartjnl-2013-304613.173","title":"GW24-e2975 Over-expression of calpastatin aggravates <i>in vitro</i> and <i>in vivo</i> cardiotoxicity induced by doxorubicin","year":2013,"lang":"en","type":"article","venue":"Heart","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Calpain; Calpastatin; Doxorubicin; Cardiotoxicity; Apoptosis; Medicine; Pharmacology; Programmed cell death; Molecular biology; Cancer research; Cell biology; Internal medicine; Biology; Biochemistry; Chemotherapy; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227116,0.0006049653,0.0005497812,0.0003085001,0.0001696201,0.0002533778,0.0001955796,0.0003675013,0.002179492],"category_scores_gemma":[0.00007811908,0.0001297269,0.0003752532,0.0002133586,0.0003059545,0.0002203064,0.0001574325,0.000887347,0.0005353634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002138545,"about_ca_system_score_gemma":0.0001831625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007087101,"about_ca_topic_score_gemma":0.000984657,"domain_scores_codex":[0.9998212,0.00001754736,0.00002467359,0.00003551317,0.00003362579,0.0000674858],"domain_scores_gemma":[0.9998755,0.000008957522,0.00003765716,0.00001047938,0.000006705746,0.00006070892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002206459,0.00006880023,0.0001404374,0.00004978773,0.000008950281,0.0001124019,0.000006957702,0.00004747467,0.9983511,0.00005147153,0.0001544328,0.0007875955],"study_design_scores_gemma":[0.0001053111,0.001738317,0.009820966,0.00001926488,0.00006626399,0.001062568,0.00006610695,0.001082135,0.9816056,0.0000766267,0.004343393,0.00001351326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911492,0.00218657,0.002263263,0.0003336977,0.0001754391,0.00007906999,0.0007907873,0.0003531839,0.002668714],"genre_scores_gemma":[0.9919952,0.001311227,0.001024768,0.0002197339,0.00002865814,0.00008406902,0.00102803,0.00004289332,0.004265446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002179492,"threshold_uncertainty_score":0.007291138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00474396977793912,"score_gpt":0.219449771588388,"score_spread":0.2147058018104489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}