{"id":"W2000358254","doi":"10.1074/jbc.m412713200","title":"MCP-1 Is Induced by Receptor Activator of Nuclear Factor-κB Ligand, Promotes Human Osteoclast Fusion, and Rescues Granulocyte Macrophage Colony-stimulating Factor Suppression of Osteoclast Formation","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Osteoclast; Activator (genetics); Granulocyte macrophage colony-stimulating factor receptor; Cell biology; Ligand (biochemistry); Chemistry; Granulocyte macrophage colony-stimulating factor; Macrophage colony-stimulating factor; Granulocyte; Macrophage; Cell fusion; Receptor; Cancer research; Immunology; Biology; Cell; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001324851,0.0002159025,0.0004243209,0.00002939621,0.00009770889,0.00002154967,0.0002024785,0.0003773192,0.0001658351],"category_scores_gemma":[0.0002895285,0.0001533476,0.0001679064,0.00006844965,0.000142694,0.00003246048,0.0001543216,0.0002046253,8.34784e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001741783,"about_ca_system_score_gemma":0.0000370916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004081197,"about_ca_topic_score_gemma":4.502959e-7,"domain_scores_codex":[0.9986069,0.00006675081,0.000680876,0.000229273,0.000217665,0.0001985111],"domain_scores_gemma":[0.9986108,0.00003987296,0.0007720932,0.0001811172,0.0002232616,0.0001728507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005131215,0.0001649078,0.003700815,0.0001243016,0.00003397846,9.186144e-7,0.0001208471,0.000001125875,0.9925881,6.197174e-7,0.00094102,0.001810247],"study_design_scores_gemma":[0.001096545,0.0005603376,0.007680594,0.0001102739,0.00002314503,0.00001466184,0.0001580914,0.00001090769,0.9870979,0.000008731266,0.003073756,0.000165066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984403,0.0008680635,0.00001056653,0.0001155041,0.00003956802,0.0001225209,0.0003206781,0.000006688164,0.00007605946],"genre_scores_gemma":[0.9989353,0.0002729953,0.0003713135,0.00005068992,0.0002327058,0.000001710744,0.00007886131,0.0000151054,0.00004133937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005490208,"threshold_uncertainty_score":0.6253335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01731350446640938,"score_gpt":0.2598557535444098,"score_spread":0.2425422490780004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}