{"id":"W2000373428","doi":"10.1021/ja7109025","title":"Rh-Catalyzed Carbonyl Hydroacylation:  An Enantioselective Approach to Lactones","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Hydroacylation; Chemistry; Enantioselective synthesis; Decarbonylation; Regioselectivity; Ligand (biochemistry); Phosphine; Salicylaldehyde; Catalysis; Aldehyde; Organic chemistry; Stereochemistry; Medicinal chemistry; Schiff base; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001884843,0.0004252683,0.0002146074,0.0001562758,0.0001406483,0.0002479883,0.0003091859,0.0001733125,0.001281019],"category_scores_gemma":[0.0001495813,0.0001237416,0.0001894324,0.0001062163,0.0002979548,0.0002813305,0.0003965538,0.0005619336,0.0008668342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002813937,"about_ca_system_score_gemma":0.0002926256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000392397,"about_ca_topic_score_gemma":0.0008000104,"domain_scores_codex":[0.9998823,0.00002000562,0.000009677294,0.00002362328,0.00002909146,0.00003528967],"domain_scores_gemma":[0.9999443,0.000008295122,0.00001364065,0.000009517426,0.000008213819,0.00001607941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000134861,0.00006124279,0.0002057251,0.000196258,0.00001334686,0.000554485,0.0001226689,0.0006571147,0.9799796,0.002240216,0.0004061716,0.01542829],"study_design_scores_gemma":[0.00003079069,0.0002038759,0.0003218838,0.000008138531,0.00001248825,0.0005345653,0.00002739743,0.0007116849,0.9853719,0.0001571253,0.01260739,0.00001277573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9131413,0.006007161,0.04481579,0.0008946173,0.0002343465,0.0002363091,0.0005660305,0.0005892408,0.03351525],"genre_scores_gemma":[0.9779578,0.003067669,0.01288106,0.000128549,0.00005047391,0.00004228174,0.0001997306,0.00005315314,0.005619287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281019,"threshold_uncertainty_score":0.004285455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02539616475597112,"score_gpt":0.28207468655017,"score_spread":0.2566785217941989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}