{"id":"W2000393832","doi":"10.1002/bit.24771","title":"Zonal rate model for axial and radial flow membrane chromatography. Part I: Knowledge transfer across operating conditions and scales","year":2012,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Bayer HealthCare","keywords":"Capsule; Volumetric flow rate; Membrane; Flow (mathematics); Calibration; Chemistry; Scale (ratio); Homogeneous; Mechanics; Chromatography; Biological system; Bovine serum albumin; Analytical Chemistry (journal); Materials science; Thermodynamics; Physics; Mathematics; Geology; Statistics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002733854,0.001588682,0.0009397357,0.001090972,0.0004717703,0.001659296,0.004136269,0.002257864,0.003646576],"category_scores_gemma":[0.004260846,0.0008443338,0.001967954,0.0009307279,0.0009265054,0.002749417,0.001522351,0.00190345,0.00237699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002335771,"about_ca_system_score_gemma":0.002004952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0136971,"about_ca_topic_score_gemma":0.004856357,"domain_scores_codex":[0.9989449,0.0002586528,0.00006021786,0.0002772159,0.0003342064,0.0001248026],"domain_scores_gemma":[0.9988045,0.0004521125,0.0002236589,0.0001972342,0.000284442,0.00003819521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002063195,0.00009409467,0.001907122,0.0005424455,0.0001468168,0.0002940377,0.0001453778,0.7980071,0.02464301,0.1271214,0.003564928,0.04332726],"study_design_scores_gemma":[0.000008691444,0.00003203219,0.0002174694,0.000009738709,0.00001407737,0.00004663569,0.00000867293,0.9875838,0.001965182,0.005740858,0.004353891,0.00001902687],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.01167342,0.001796638,0.9772175,0.0006213209,0.0001546605,0.000287046,0.0007012151,0.000840692,0.006707525],"genre_scores_gemma":[0.4993847,0.005647146,0.4544062,0.000860772,0.000208038,0.003012701,0.002428293,0.0006579802,0.0333941],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0136971,"threshold_uncertainty_score":0.02723473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414112967166801,"score_gpt":0.2568937251671926,"score_spread":0.2427525954955246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}