{"id":"W2000395148","doi":"10.1160/th09-08-0557","title":"Calpain inhibition by calpeptin does not prevent APLT activity reduction in PS-exposing platelets, but calpeptin has independent pro-apoptotic effects","year":2010,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Calpain; Platelet; Reduction (mathematics); Apoptosis; Chemistry; Cell biology; Materials science; Medicine; Internal medicine; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670999,0.0003980985,0.000516132,0.0001571921,0.00009719721,0.0003427903,0.0002711267,0.0004012178,0.001378703],"category_scores_gemma":[0.0003111609,0.0001147122,0.0002847638,0.0001742831,0.0002571738,0.0002158251,0.0001421662,0.001135411,0.0003041293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002777393,"about_ca_system_score_gemma":0.0002479659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000617464,"about_ca_topic_score_gemma":0.0007137539,"domain_scores_codex":[0.9997713,0.00002512577,0.00002885028,0.00004785549,0.00007418595,0.0000527594],"domain_scores_gemma":[0.9997783,0.00006686789,0.00005169418,0.00003506467,0.00002971133,0.00003834704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002421888,0.00008075298,0.00009968942,0.00004492244,0.00001127296,0.00008973259,0.00001441918,0.00003228836,0.9976115,0.00004953005,0.00007066962,0.001653029],"study_design_scores_gemma":[0.00003670123,0.0003509543,0.003084286,0.000003864383,0.00001383692,0.0002722865,0.000007949719,0.00054699,0.9943821,0.00002592887,0.001272959,0.000001976117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875824,0.005073738,0.004071486,0.0002981467,0.0001335391,0.0001033456,0.0004886906,0.0001372443,0.002111395],"genre_scores_gemma":[0.9899832,0.001938017,0.003202132,0.0001949765,0.00005282971,0.000100932,0.0009591411,0.00002669142,0.003542158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378703,"threshold_uncertainty_score":0.004612267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291589968987206,"score_gpt":0.2912977200979095,"score_spread":0.2621387231991889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}