{"id":"W2000421237","doi":"10.1016/j.taap.2004.12.028","title":"Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case of the aryl hydrocarbon receptor","year":2005,"lang":"en","type":"review","venue":"Toxicology and Applied Pharmacology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Aryl hydrocarbon receptor; CYP1B1; Xenobiotic; Transactivation; Receptor; Pregnane X receptor; Toxicity; Nuclear receptor; Biology; Gene; Chemistry; Biochemistry; Gene expression; Transcription factor; Cytochrome P450; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007083089,0.0003988034,0.001321201,0.00007846914,0.0001556216,0.000004306135,0.000831287,0.0007797057,0.002624117],"category_scores_gemma":[0.00009469761,0.000233959,0.0002388987,0.0005638116,0.00177106,0.00002980655,0.0005003894,0.000682216,0.00002453753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003163308,"about_ca_system_score_gemma":0.0001366668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000117817,"about_ca_topic_score_gemma":0.00005647737,"domain_scores_codex":[0.9975678,0.0002688821,0.0009673356,0.0005640254,0.00008499612,0.0005469642],"domain_scores_gemma":[0.9972696,0.001430466,0.0007572168,0.0004228858,0.000002770048,0.0001171145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006626768,0.0004282266,0.00002954512,0.0002097476,0.0001303753,0.0000044811,0.000165892,0.0000107697,0.06207573,0.0004663227,0.002708133,0.9337045],"study_design_scores_gemma":[0.002522836,0.0005455982,0.001010118,0.0002778873,0.00227386,0.001743306,0.0001217667,0.00004740969,0.03432609,0.001498265,0.9546462,0.0009866735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1469525,0.833224,0.00002321118,0.004349545,0.001407632,0.009870107,0.0008943737,0.00007176537,0.003206843],"genre_scores_gemma":[0.4996375,0.4983551,0.0002379247,0.0008262045,0.0001795849,0.0005579047,0.000007239368,0.00005179656,0.0001467911],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.951938,"threshold_uncertainty_score":0.9982876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03393525318590081,"score_gpt":0.3314902208068232,"score_spread":0.2975549676209224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}