{"id":"W2000427756","doi":"10.1016/j.jmb.2010.07.016","title":"The PAX3 Paired Domain and Homeodomain Function as a Single Binding Module In Vivo to Regulate Subnuclear Localization and Mobility by a Mechanism That Requires Base-Specific Recognition","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"PAX3; Biology; Homeobox; Mutant; Transcription factor; Heterochromatin; Cell biology; Genetics; Nuclear localization sequence; DNA; Chromatin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000265958,0.000379138,0.0003646647,0.0002197412,0.000392614,0.0005537244,0.0005803884,0.0003800494,0.002150856],"category_scores_gemma":[0.0002339049,0.0005235688,0.0003849051,0.0001987792,0.0004392224,0.0007038879,0.00097194,0.000768405,0.001076435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004643363,"about_ca_system_score_gemma":0.0003268225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004985342,"about_ca_topic_score_gemma":0.001256187,"domain_scores_codex":[0.9997852,0.00002643095,0.000009936023,0.00005945586,0.00007256387,0.00004635212],"domain_scores_gemma":[0.999837,0.00003196469,0.00003443616,0.00003111674,0.00001282679,0.0000525472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009577887,0.000008002415,0.0003401412,0.00001206464,0.00000851,0.00002534707,0.00001186078,0.0001052671,0.9967021,0.0006690522,0.00003925393,0.001982578],"study_design_scores_gemma":[0.0000182741,0.00004058352,0.002323303,0.000001695204,0.00001035821,0.0002374737,0.0000184629,0.002126152,0.9937831,0.0003886806,0.001044735,0.000007310318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640066,0.0006668075,0.03241794,0.00008378676,0.00004458709,0.00002342964,0.0001829628,0.0003277303,0.002246226],"genre_scores_gemma":[0.9887499,0.0001339083,0.008352432,0.00004918671,0.000009199225,0.00001962743,0.0002629684,0.00006937019,0.002353519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002150856,"threshold_uncertainty_score":0.007195354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008199471553769159,"score_gpt":0.2096109555345569,"score_spread":0.2014114839807878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}