{"id":"W2000429600","doi":"10.1021/ja0550428","title":"Photocontrol of DNA Binding Specificity of a Miniature Engrailed Homeodomain","year":2005,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"engrailed; Chemistry; DNA; Circular dichroism; Peptide; Linker; Crystallography; Homeobox; Molecular biology; Stereochemistry; Biochemistry; Gene; Biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009788757,0.0002415396,0.000147146,0.00006215253,0.00007573962,0.0002029939,0.0001676232,0.0002025054,0.0004918332],"category_scores_gemma":[0.0001453422,0.0001014845,0.000147182,0.00005445628,0.0002656069,0.0001055593,0.0001243576,0.0004036625,0.0001752653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002848265,"about_ca_system_score_gemma":0.0000947401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000377715,"about_ca_topic_score_gemma":0.0006833489,"domain_scores_codex":[0.9998975,0.00001638242,0.000005711842,0.00003065332,0.00002957089,0.00002016675],"domain_scores_gemma":[0.999872,0.00004358147,0.0000369098,0.00001231644,0.00001082018,0.0000243024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001467161,0.000002769226,0.00003758334,0.000005453618,0.000001165213,0.000006297606,0.000004798136,0.00002540832,0.9996996,0.00001837062,0.000002298292,0.0001815465],"study_design_scores_gemma":[0.00000535075,0.00006799719,0.001620705,0.000001161587,0.000002838893,0.00006091515,0.000008479768,0.0006298138,0.9972234,0.00001333701,0.0003635865,0.000002499492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997595,0.0002546126,0.001671405,0.00001919637,0.000006328686,0.000006975717,0.00003588377,0.00003530656,0.0003753232],"genre_scores_gemma":[0.9981123,0.0001308006,0.001157018,0.00001959657,0.000001761009,0.000004861819,0.00005704992,0.00001174612,0.0005046865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004918332,"threshold_uncertainty_score":0.002066553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004717883635598183,"score_gpt":0.2273705687803303,"score_spread":0.2226526851447321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}