{"id":"W2000457498","doi":"10.1016/j.str.2010.11.005","title":"FHA Domain pThr Binding Specificity: It's All about Me","year":2010,"lang":"en","type":"letter","venue":"Structure","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Threonine; Serine; Domain (mathematical analysis); Binding domain; Computational biology; Peptide; Biochemistry; Chemistry; Binding site; Binding selectivity; Biology; Phosphorylation; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008186116,0.0005049268,0.0006274293,0.0002136012,0.001525163,0.00175846,0.0007093059,0.01173562,0.004138584],"category_scores_gemma":[0.002671265,0.0003214653,0.0004492092,0.0001824955,0.00227179,0.001854432,0.0007733341,0.01623699,0.002059434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002594921,"about_ca_system_score_gemma":0.0008808672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001662836,"about_ca_topic_score_gemma":0.00220111,"domain_scores_codex":[0.9995996,0.00007738846,0.00002638228,0.00006782288,0.0001449514,0.00008389149],"domain_scores_gemma":[0.9993787,0.0002170625,0.00006604745,0.00004510398,0.00009891059,0.0001942696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002855636,0.00005494525,0.0009158262,0.0001183063,0.00003784248,0.004293781,0.0002121701,0.0001301517,0.006242117,0.01380813,0.9341807,0.03972055],"study_design_scores_gemma":[0.0002553667,0.0001050571,0.001827924,0.000109018,0.00005284944,0.007719078,0.000563544,0.0006577536,0.003662597,0.03469016,0.9502773,0.0000793868],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0017898,0.004698734,0.000404345,0.9744922,0.01442376,0.00000625527,0.00002932638,0.00004917459,0.004106542],"genre_scores_gemma":[0.05622182,0.007758919,0.001150118,0.8557894,0.04366491,0.00003541126,0.00006768753,0.00003712913,0.03527466],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01173562,"threshold_uncertainty_score":0.01882756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049306069087782,"score_gpt":0.2463290913325669,"score_spread":0.235836030641689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}