{"id":"W2000457498","doi":"10.1016/j.str.2010.11.005","title":"FHA Domain pThr Binding Specificity: It's All about Me","year":2010,"lang":"en","type":"letter","venue":"Structure","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Threonine; Serine; Domain (mathematical analysis); Binding domain; Computational biology; Peptide; Biochemistry; Chemistry; Binding site; Binding selectivity; Biology; Phosphorylation; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.000126293,0.0004970114,0.000362775,0.0001230176,0.0001478326,0.0001123633,0.0004411041,0.003430279,0.0008991327],"category_scores_gemma":[0.00004102555,0.0004541783,0.0002520537,0.0000948107,0.0001371557,0.000003998047,0.0001620691,0.002507894,0.00003448925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003072139,"about_ca_system_score_gemma":0.0001112104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009144384,"about_ca_topic_score_gemma":0.00003210966,"domain_scores_codex":[0.9979137,0.00009450111,0.000335302,0.0007652314,0.0003610251,0.0005302619],"domain_scores_gemma":[0.9987546,0.00001110774,0.0002598241,0.0007830881,0.00009255739,0.00009878885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001314407,0.000002639531,0.00001474989,0.0000623126,0.00007339517,0.00007227608,0.00002592359,0.000004962648,0.5114677,0.00003457567,0.4878204,0.0004079226],"study_design_scores_gemma":[0.0002815347,0.00003426495,0.0000292483,0.00005199681,0.00003688062,0.00008100755,0.00001403784,0.000003817358,0.1345249,0.0008439454,0.8636115,0.0004868582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3053558,0.004932711,0.003075009,0.6627947,0.006688947,0.002405209,0.004058146,0.0002407384,0.01044876],"genre_scores_gemma":[0.06669484,0.0002913021,0.01004806,0.8411648,0.04305774,0.00005583186,0.02614263,0.0004134595,0.01213132],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3769428,"threshold_uncertainty_score":0.9997934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049306069087782,"score_gpt":0.2463290913325669,"score_spread":0.235836030641689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}