{"id":"W2000460543","doi":"10.1016/j.bmc.2008.03.059","title":"Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Killam Trusts; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Mode of action; Enzyme; Enzyme inhibitor; Hepatitis C virus; Biochemistry; Virus; Stereochemistry; Combinatorial chemistry; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003407133,0.0004580858,0.0004392017,0.0003192024,0.0001707531,0.0002306798,0.0003517507,0.0002843265,0.002365843],"category_scores_gemma":[0.0001628075,0.0001571658,0.0002928156,0.0001860875,0.0001612365,0.0002341028,0.0001321028,0.0004476838,0.0003342917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002659675,"about_ca_system_score_gemma":0.0002766174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008500479,"about_ca_topic_score_gemma":0.001852151,"domain_scores_codex":[0.9998989,0.00002365753,0.000005835103,0.00001249759,0.00002170896,0.00003742311],"domain_scores_gemma":[0.999943,0.00001588416,0.00001129331,0.000006303262,0.000008073027,0.00001539279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00582273,0.001109047,0.0005462713,0.0001920011,0.00007887859,0.000319675,0.0000718332,0.002465817,0.9587151,0.0006735101,0.0004097,0.02959547],"study_design_scores_gemma":[0.001149702,0.01775428,0.002555301,0.00002232206,0.0001541105,0.0006971012,0.00003615358,0.003290046,0.9690107,0.0001584645,0.005140323,0.00003150807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984364,0.006562363,0.002782023,0.0001127152,0.00004996187,0.0001646196,0.0002777729,0.00007381198,0.005612778],"genre_scores_gemma":[0.9910356,0.004228647,0.001489046,0.00006658029,0.00002601103,0.00004098803,0.0002527039,0.00001196904,0.002848451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002365843,"threshold_uncertainty_score":0.007914603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06740366296933235,"score_gpt":0.3601271727814334,"score_spread":0.292723509812101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}