{"id":"W2000460543","doi":"10.1016/j.bmc.2008.03.059","title":"Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Killam Trusts; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Mode of action; Enzyme; Enzyme inhibitor; Hepatitis C virus; Biochemistry; Virus; Stereochemistry; Combinatorial chemistry; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004773063,0.0001640425,0.0004686778,0.00009531442,0.00003004492,0.000001736808,0.0001300165,0.0001783243,0.0001355467],"category_scores_gemma":[0.0006206422,0.0001416506,0.0001142944,0.000356119,0.0003164472,0.00006387384,0.00004343168,0.0002092829,0.000005841902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013937,"about_ca_system_score_gemma":0.0008213089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104933,"about_ca_topic_score_gemma":0.0000225455,"domain_scores_codex":[0.997327,0.00005861931,0.0006178538,0.0002431634,0.001553507,0.0001999086],"domain_scores_gemma":[0.998592,0.0000575556,0.0003368767,0.0004140717,0.0005430377,0.00005642342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002451043,0.0002927133,0.02038729,0.001726076,0.00007587843,0.0000161394,0.0005538734,3.441698e-7,0.9745048,4.856885e-7,0.0001137727,0.002083562],"study_design_scores_gemma":[0.002053541,0.0003348284,0.009128583,0.0006682948,0.000206772,0.0001717887,0.0001676002,0.0006806577,0.9863553,0.00003777752,0.00009945186,0.00009540633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981104,0.0006052657,0.00006259488,0.00007035111,0.00005892867,0.0005088142,0.00001202216,0.00002098409,0.0005506625],"genre_scores_gemma":[0.9993642,0.00003059638,0.00009331557,0.0002318494,0.0001776189,0.00003982939,0.0000120714,0.00002277989,0.00002775753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01185054,"threshold_uncertainty_score":0.5776346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06740366296933235,"score_gpt":0.3601271727814334,"score_spread":0.292723509812101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}