{"id":"W2000463520","doi":"10.1021/bi4003869","title":"Efficacy as an Intrinsic Property of the M<sub>2</sub>Muscarinic Receptor in Its Tetrameric State","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Muscarinic acetylcholine receptor; Property (philosophy); Chemistry; State (computer science); Crystallography; Thermodynamics; Stereochemistry; Biophysics; Receptor; Chromatography; Biochemistry; Mathematics; Physics; Philosophy; Biology; Epistemology; Algorithm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009274482,0.0003979222,0.0004860932,0.0004354964,0.0002309698,0.001048449,0.000620942,0.0005856167,0.00142085],"category_scores_gemma":[0.0008577156,0.0003668089,0.0003105075,0.0002714679,0.000643616,0.0007769983,0.0003944182,0.00103297,0.000667277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007085486,"about_ca_system_score_gemma":0.0001362398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002881786,"about_ca_topic_score_gemma":0.0003562127,"domain_scores_codex":[0.999138,0.000150858,0.00008298601,0.0001877784,0.0003117142,0.0001285864],"domain_scores_gemma":[0.999281,0.0001747185,0.0001537694,0.0001866035,0.0001210827,0.00008290241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007164585,0.00002129345,0.001103564,0.00002753283,0.0000159862,0.00002230468,0.00004350591,0.0000966846,0.9973146,0.0003290383,0.0000245826,0.0009291933],"study_design_scores_gemma":[0.00002748351,0.0004694218,0.04646742,0.00001544985,0.00006305707,0.0004741026,0.00007024582,0.00554002,0.9446132,0.0002870623,0.001956691,0.00001582476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918666,0.0006076455,0.005370469,0.00005636392,0.00001027081,0.00002498397,0.0001944923,0.00007689311,0.001792239],"genre_scores_gemma":[0.9959001,0.0002670084,0.002221943,0.00005605592,0.00001348647,0.00004897297,0.0005815752,0.0000320204,0.0008788354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142085,"threshold_uncertainty_score":0.005140901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007587984473879393,"score_gpt":0.2174004779326518,"score_spread":0.2098124934587724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}