{"id":"W2000463520","doi":"10.1021/bi4003869","title":"Efficacy as an Intrinsic Property of the M<sub>2</sub>Muscarinic Receptor in Its Tetrameric State","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Muscarinic acetylcholine receptor; Property (philosophy); Chemistry; State (computer science); Crystallography; Thermodynamics; Stereochemistry; Biophysics; Receptor; Chromatography; Biochemistry; Mathematics; Physics; Philosophy; Biology; Epistemology; Algorithm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509815,0.0002080233,0.0001897569,0.00002632064,0.00005122572,0.00003053361,0.0004167439,0.0001960272,0.0001391953],"category_scores_gemma":[0.0001639263,0.0001363535,0.0001177853,0.0001940228,0.00009037828,0.00000843477,0.000168876,0.0001782922,0.0000426361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000266175,"about_ca_system_score_gemma":0.0001643697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006104405,"about_ca_topic_score_gemma":0.000005382209,"domain_scores_codex":[0.9986861,0.00006696836,0.0003283316,0.0004347586,0.0001812773,0.0003025473],"domain_scores_gemma":[0.9990697,0.00001124658,0.0001489167,0.0005415591,0.0001152961,0.0001133056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004162511,0.0001322299,0.000345466,0.00004033283,0.00002093727,5.51447e-7,0.00004712172,0.00001691941,0.9861118,0.000003457153,0.0004095693,0.01283005],"study_design_scores_gemma":[0.0004781845,0.0001435309,0.001496607,0.00004933355,0.000006055682,0.000006260677,0.00008681115,0.0000329679,0.9967665,0.00003364978,0.0006870746,0.0002130163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986137,0.0003285579,0.00001313815,0.00007169664,0.0001483319,0.0003512677,0.00001106999,0.00001309703,0.0004491745],"genre_scores_gemma":[0.9987839,0.000164673,0.0001151987,0.0001184663,0.0001357046,0.00004955757,0.00005000325,0.00003141773,0.0005510678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01261703,"threshold_uncertainty_score":0.5560334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007587984473879393,"score_gpt":0.2174004779326518,"score_spread":0.2098124934587724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}